Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

COMMIT-KZN Team

doi:10.1038/s41467-022-32396-9

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

COMMIT-KZN Team

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.

Original language	English
Article number	4686
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-32396-9
Publication status	Published - Dec 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
Multidisciplinary
General Physics and Astronomy

Access to Document

10.1038/s41467-022-32396-9

Cite this

@article{110f996f45b0443194cb5a4fff5f3ea5,

title = "Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection",

abstract = "SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.",

author = "\{COMMIT-KZN Team\} and Khadija Khan and Farina Karim and Yashica Ganga and Mallory Bernstein and Zesuliwe Jule and Kajal Reedoy and Sandile Cele and Gila Lustig and Daniel Amoako and Nicole Wolter and Natasha Samsunder and Aida Sivro and San, \{James Emmanuel\} and Jennifer Giandhari and Houriiyah Tegally and Sureshnee Pillay and Yeshnee Naidoo and Matilda Mazibuko and Yoliswa Miya and Nokuthula Ngcobo and Nithendra Manickchund and Nombulelo Magula and Karim, \{Quarraisha Abdool\} and \{von Gottberg\}, Anne and \{Abdool Karim\}, \{Salim S.\} and Willem Hanekom and Gosnell, \{Bernadett I.\} and Thandeka Khoza and Theresa Smit and Emily Wong and Lessells, \{Richard J.\} and \{de Oliveira\}, Tulio and Moosa, \{Mahomed Yunus S.\} and Alex Sigal",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-32396-9",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

AU - COMMIT-KZN Team

AU - Khan, Khadija

AU - Karim, Farina

AU - Ganga, Yashica

AU - Bernstein, Mallory

AU - Jule, Zesuliwe

AU - Reedoy, Kajal

AU - Cele, Sandile

AU - Lustig, Gila

AU - Amoako, Daniel

AU - Wolter, Nicole

AU - Samsunder, Natasha

AU - Sivro, Aida

AU - San, James Emmanuel

AU - Giandhari, Jennifer

AU - Tegally, Houriiyah

AU - Pillay, Sureshnee

AU - Naidoo, Yeshnee

AU - Mazibuko, Matilda

AU - Miya, Yoliswa

AU - Ngcobo, Nokuthula

AU - Manickchund, Nithendra

AU - Magula, Nombulelo

AU - Karim, Quarraisha Abdool

AU - von Gottberg, Anne

AU - Abdool Karim, Salim S.

AU - Hanekom, Willem

AU - Gosnell, Bernadett I.

AU - Khoza, Thandeka

AU - Smit, Theresa

AU - Wong, Emily

AU - Lessells, Richard J.

AU - de Oliveira, Tulio

AU - Moosa, Mahomed Yunus S.

AU - Sigal, Alex

PY - 2022/12

Y1 - 2022/12

N2 - SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.

AB - SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.

UR - https://www.scopus.com/pages/publications/85135803088

U2 - 10.1038/s41467-022-32396-9

DO - 10.1038/s41467-022-32396-9

M3 - Article

C2 - 35948557

AN - SCOPUS:85135803088

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 4686

ER -

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Abstract

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this