Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine

M. W. Bredenkamp; C. W. Holzapfel; R. M. Snyman; W. J. Van Zyl

doi:10.1080/00397919209409251

Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine

M. W. Bredenkamp, C. W. Holzapfel, R. M. Snyman, W. J. Van Zyl

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.

Original language	English
Pages (from-to)	3029-3039
Number of pages	11
Journal	Synthetic Communications
Volume	22
Issue number	21
DOIs	https://doi.org/10.1080/00397919209409251
Publication status	Published - 1992

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1080/00397919209409251

Cite this

@article{a47bf49615d743f1ad78fa7ba0ad2068,

title = "Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine",

abstract = "An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.",

author = "Bredenkamp, \{M. W.\} and Holzapfel, \{C. W.\} and Snyman, \{R. M.\} and \{Van Zyl\}, \{W. J.\}",

year = "1992",

doi = "10.1080/00397919209409251",

language = "English",

volume = "22",

pages = "3029--3039",

journal = "Synthetic Communications",

issn = "0039-7911",

publisher = "Taylor and Francis Ltd.",

number = "21",

}

TY - JOUR

T1 - Observations on the Hantzsch reaction

T2 - Synthesis of N-(t)Boc-S-dolaphenine

AU - Bredenkamp, M. W.

AU - Holzapfel, C. W.

AU - Snyman, R. M.

AU - Van Zyl, W. J.

PY - 1992

Y1 - 1992

N2 - An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.

AB - An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.

UR - https://www.scopus.com/pages/publications/0026674651

U2 - 10.1080/00397919209409251

DO - 10.1080/00397919209409251

M3 - Article

AN - SCOPUS:0026674651

SN - 0039-7911

VL - 22

SP - 3029

EP - 3039

JO - Synthetic Communications

JF - Synthetic Communications

IS - 21

ER -

Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this