Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine

M. W. Bredenkamp; C. W. Holzapfel; R. M. Snyman; W. J. Van Zyl

doi:10.1080/00397919209409251

Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine

M. W. Bredenkamp, C. W. Holzapfel, R. M. Snyman, W. J. Van Zyl

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.

Original language	English
Pages (from-to)	3029-3039
Number of pages	11
Journal	Synthetic Communications
Volume	22
Issue number	21
DOIs	https://doi.org/10.1080/00397919209409251
Publication status	Published - 1992

ASJC Scopus subject areas

Organic Chemistry

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10.1080/00397919209409251

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title = "Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine",

abstract = "An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.",

author = "Bredenkamp, {M. W.} and Holzapfel, {C. W.} and Snyman, {R. M.} and {Van Zyl}, {W. J.}",

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AU - Snyman, R. M.

AU - Van Zyl, W. J.

PY - 1992

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AB - An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.

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JO - Synthetic Communications

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ER -

Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine

Abstract

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