Observations on the Hantzsch reaction: Synthesis of N-(t)Boc-S-dolaphenine

M. W. Bredenkamp, C. W. Holzapfel, R. M. Snyman, W. J. Van Zyl

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-(t)Boc-S-dolaphenine (3) is then synthesized using this methodology.

Original languageEnglish
Pages (from-to)3029-3039
Number of pages11
JournalSynthetic Communications
Issue number21
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Organic Chemistry


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