Non-coding RNAs related to angiogenesis in gynecological cancer

Neda Rahimian, Zahra Sadat Razavi, Fatemeh Aslanbeigi, Amir Masoud Mirkhabbaz, Haleh Piroozmand, Mohammad Karim Shahrzad, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

Gynecological cancer affects the female reproductive system, including ovarian, uterine, endometrial, cervical, vulvar, and vaginal tumors. Non-coding RNAs (ncRNAs), and in particular microRNAs, function as regulatory molecules, which can control gene expression in a post-transcriptional manner. Normal physiological processes like cellular proliferation, differentiation, and apoptosis, and pathological processes such as oncogenesis and metastasis are regulated by microRNAs. Numerous reports have shown a direct role of microRNAs in the modulation of angiogenesis in gynecological cancer, via targeting pro-angiogenic factors and signaling pathways. Understanding the molecular mechanism involved in the regulation of angiogenesis by microRNAs may lead to new treatment options. Recently the regulatory role of some long non-coding RNAs in gynecological cancer has also been explored, but the information on this function is more limited. The aim of this article is to explore the pathways responsible for angiogenesis, and to what extent ncRNAs may be employed as biomarkers or therapeutic targets in gynecological cancer.

Original languageEnglish
Pages (from-to)896-912
Number of pages17
JournalGynecologic Oncology
Volume161
Issue number3
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Angiogenesis
  • Gynecological cancers
  • Non-coding RNAs

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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