Non-coding RNAs and glioma: Focus on cancer stem cells

Ali Rajabi, Mehrdad Kayedi, Shiva Rahimi, Fatemeh Dashti, Seyed Mohammad Ali Mirazimi, Mina Homayoonfal, Seyed Mohammad Amin Mahdian, Michael R. Hamblin, Omid Reza Tamtaji, Ali Afrasiabi, Ameneh Jafari, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Glioblastoma and gliomas can have a wide range of histopathologic subtypes. These heterogeneous histologic phenotypes originate from tumor cells with the distinct functions of tumorigenesis and self-renewal, called glioma stem cells (GSCs). GSCs are characterized based on multi-layered epigenetic mechanisms, which control the expression of many genes. This epigenetic regulatory mechanism is often based on functional non-coding RNAs (ncRNAs). ncRNAs have become increasingly important in the pathogenesis of human cancer and work as oncogenes or tumor suppressors to regulate carcinogenesis and progression. These RNAs by being involved in chromatin remodeling and modification, transcriptional regulation, and alternative splicing of pre-mRNA, as well as mRNA stability and protein translation, play a key role in tumor development and progression. Numerous studies have been performed to try to understand the dysregulation pattern of these ncRNAs in tumors and cancer stem cells (CSCs), which show robust differentiation and self-regeneration capacity. This review provides recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on CSCs, thus accelerating the clinical implementation of ncRNAs as promising tumor biomarkers and therapeutic targets.

Original languageEnglish
Pages (from-to)100-123
Number of pages24
JournalMolecular Therapy - Oncolytics
Volume27
DOIs
Publication statusPublished - 15 Dec 2022

Keywords

  • Cancer stem cells
  • Glioma
  • MT: Non-coding RNAs

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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