TY - JOUR
T1 - Non-coding RNAs and glioma
T2 - Focus on cancer stem cells
AU - Rajabi, Ali
AU - Kayedi, Mehrdad
AU - Rahimi, Shiva
AU - Dashti, Fatemeh
AU - Mirazimi, Seyed Mohammad Ali
AU - Homayoonfal, Mina
AU - Mahdian, Seyed Mohammad Amin
AU - Hamblin, Michael R.
AU - Tamtaji, Omid Reza
AU - Afrasiabi, Ali
AU - Jafari, Ameneh
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/12/15
Y1 - 2022/12/15
N2 - Glioblastoma and gliomas can have a wide range of histopathologic subtypes. These heterogeneous histologic phenotypes originate from tumor cells with the distinct functions of tumorigenesis and self-renewal, called glioma stem cells (GSCs). GSCs are characterized based on multi-layered epigenetic mechanisms, which control the expression of many genes. This epigenetic regulatory mechanism is often based on functional non-coding RNAs (ncRNAs). ncRNAs have become increasingly important in the pathogenesis of human cancer and work as oncogenes or tumor suppressors to regulate carcinogenesis and progression. These RNAs by being involved in chromatin remodeling and modification, transcriptional regulation, and alternative splicing of pre-mRNA, as well as mRNA stability and protein translation, play a key role in tumor development and progression. Numerous studies have been performed to try to understand the dysregulation pattern of these ncRNAs in tumors and cancer stem cells (CSCs), which show robust differentiation and self-regeneration capacity. This review provides recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on CSCs, thus accelerating the clinical implementation of ncRNAs as promising tumor biomarkers and therapeutic targets.
AB - Glioblastoma and gliomas can have a wide range of histopathologic subtypes. These heterogeneous histologic phenotypes originate from tumor cells with the distinct functions of tumorigenesis and self-renewal, called glioma stem cells (GSCs). GSCs are characterized based on multi-layered epigenetic mechanisms, which control the expression of many genes. This epigenetic regulatory mechanism is often based on functional non-coding RNAs (ncRNAs). ncRNAs have become increasingly important in the pathogenesis of human cancer and work as oncogenes or tumor suppressors to regulate carcinogenesis and progression. These RNAs by being involved in chromatin remodeling and modification, transcriptional regulation, and alternative splicing of pre-mRNA, as well as mRNA stability and protein translation, play a key role in tumor development and progression. Numerous studies have been performed to try to understand the dysregulation pattern of these ncRNAs in tumors and cancer stem cells (CSCs), which show robust differentiation and self-regeneration capacity. This review provides recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on CSCs, thus accelerating the clinical implementation of ncRNAs as promising tumor biomarkers and therapeutic targets.
KW - Cancer stem cells
KW - Glioma
KW - MT: Non-coding RNAs
UR - http://www.scopus.com/inward/record.url?scp=85140318903&partnerID=8YFLogxK
U2 - 10.1016/j.omto.2022.09.005
DO - 10.1016/j.omto.2022.09.005
M3 - Review article
AN - SCOPUS:85140318903
SN - 2372-7705
VL - 27
SP - 100
EP - 123
JO - Molecular Therapy - Oncolytics
JF - Molecular Therapy - Oncolytics
ER -