TY - JOUR
T1 - Non-coding RNAs and glioblastoma
T2 - Insight into their roles in metastasis
AU - Mousavi, Seyed Mojtaba
AU - Derakhshan, Maryam
AU - Baharloii, Fatereh
AU - Dashti, Fatemeh
AU - Mirazimi, Seyed Mohammad Ali
AU - Mahjoubin-Tehran, Maryam
AU - Hosseindoost, Saereh
AU - Goleij, Pouya
AU - Rahimian, Neda
AU - Hamblin, Michael R.
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2022/3/17
Y1 - 2022/3/17
N2 - Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate among all primary brain malignancies. Metastasis occurs as the tumor cells spread from the site of origin to another site in the brain. Metastasis is a multifactorial process, which depends on alterations in metabolism, genetic mutations, and the cancer microenvironment. During recent years, the scientific study of non-coding RNAs (ncRNAs) has led to new insight into the molecular mechanisms involved in glioma. Many studies have reported that ncRNAs play major roles in many biological procedures connected with the development and progression of glioma. Long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are all types of ncRNAs, which are commonly dysregulated in GBM. Dysregulation of ncRNAs can facilitate the invasion and metastasis of glioma. The present review highlights some ncRNAs that have been associated with metastasis in GBM. miRNAs, circRNAs, and lncRNAs are discussed in detail with respect to their relevant signaling pathways involved in metastasis.
AB - Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate among all primary brain malignancies. Metastasis occurs as the tumor cells spread from the site of origin to another site in the brain. Metastasis is a multifactorial process, which depends on alterations in metabolism, genetic mutations, and the cancer microenvironment. During recent years, the scientific study of non-coding RNAs (ncRNAs) has led to new insight into the molecular mechanisms involved in glioma. Many studies have reported that ncRNAs play major roles in many biological procedures connected with the development and progression of glioma. Long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are all types of ncRNAs, which are commonly dysregulated in GBM. Dysregulation of ncRNAs can facilitate the invasion and metastasis of glioma. The present review highlights some ncRNAs that have been associated with metastasis in GBM. miRNAs, circRNAs, and lncRNAs are discussed in detail with respect to their relevant signaling pathways involved in metastasis.
KW - circular RNA
KW - glioblastoma
KW - long non-coding RNA
KW - metastasis
KW - microRNA
KW - non-coding RNA
UR - http://www.scopus.com/inward/record.url?scp=85122654898&partnerID=8YFLogxK
U2 - 10.1016/j.omto.2021.12.015
DO - 10.1016/j.omto.2021.12.015
M3 - Review article
AN - SCOPUS:85122654898
SN - 2372-7705
VL - 24
SP - 262
EP - 287
JO - Molecular Therapy - Oncolytics
JF - Molecular Therapy - Oncolytics
ER -
