Non-coding RNAs and exosomal non-coding RNAs in pituitary adenoma

Neda Rahimian, Amirhossein Sheida, Mohammadreza Rajabi, Mohammad Mahdi Heidari, Mohammad Tobeiha, Pegah Veradi Esfahani, Sahar Ahmadi Asouri, Michael R. Hamblin, Omid Mohamadzadeh, Alireza Motamedzadeh, Mahmood Khaksary Mahabady

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Pituitary adenoma (PA) is the third most common primary intracranial tumor in terms of overall disease incidence. Although they are benign tumors, they can have a variety of clinical symptoms, but are mostly asymptomatic, which often leads to diagnosis at an advanced stage when surgical intervention is ineffective. Earlier identification of PA could reduce morbidity and allow better clinical management of the affected patients. Non-coding RNAs (ncRNAs) do not generally code for proteins, but can modulate biological processes at the post-transcriptional level through a variety of molecular mechanisms. An increased number of ncRNA expression profiles have been found in PAs. Therefore, understanding the expression patterns of different ncRNAs could be a promising method for developing non-invasive biomarkers. This review summarizes the expression patterns of dysregulated ncRNAs (microRNAs, long non-coding RNAs, and circular RNAs) involved in PA, which could one day serve as innovative biomarkers or therapeutic targets for the treatment of this neoplasia. We also discuss the potential molecular pathways by which the dysregulated ncRNAs could cause PA and affect its progression.

Original languageEnglish
Article number154649
JournalPathology Research and Practice
Volume248
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Circular RNAs
  • Exosomes
  • Long non-coding RNAs
  • MicroRNAs
  • Non-coding RNAs
  • Pituitary adenomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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