Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis

Omid Reza Tamtaji, Maryam Derakhshan, Fatemeh Zahra Rashidi Noshabad, Javad Razaviyan, Razie Hadavi, Hamed Jafarpour, Ameneh Jafari, Ali Rajabi, Michael R. Hamblin, Mahmood Khaksary Mahabady, Mohammad Taghizadieh, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


A major terrifying ailment afflicting the humans throughout the world is brain tumor, which causes a lot of mortality among pediatric and adult solid tumors. Several major barriers to the treatment and diagnosis of the brain tumors are the specific micro-environmental and cell-intrinsic features of neural tissues. Absence of the nutrients and hypoxia trigger the cells’ mortality in the core of the tumors of humans’ brains: however, type of the cells’ mortality, including apoptosis or necrosis, has been not found obviously. Current studies have emphasized the non-coding RNAs (ncRNAs) since their crucial impacts on carcinogenesis have been discovered. Several investigations suggest the essential contribution of such molecules in the development of brain tumors and the respective roles in apoptosis. Herein, we summarize the apoptosis-related non-coding RNAs in brain tumors.

Original languageEnglish
Article number792185
JournalFrontiers in Cell and Developmental Biology
Publication statusPublished - 17 Jan 2022


  • apoptosis
  • brain tumors
  • long non-coding (lnc) RNA
  • microRNA
  • non-coding RNAs

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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