Noble metal nanoparticles in biosensors: Recent studies and applications

Hedieh Malekzad, Parham Sahandi Zangabad, Hamed Mirshekari, Mahdi Karimi, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

266 Citations (Scopus)


The aim of this review is to cover advances in noble metal nanoparticle (MNP)-based biosensors and to outline the principles and main functions of MNPs in different classes of biosensors according to the transduction methods employed. The important biorecognition elements are enzymes, antibodies, aptamers, DNA sequences, and whole cells. The main readouts are electrochemical (amperometric and voltametric), optical (surface plasmon resonance, colorimetric, chemiluminescence, photoelectrochemical, etc.) and piezoelectric. MNPs have received attention for applications in biosensing due to their fascinating properties. These properties include a large surface area that enhances biorecognizers and receptor immobilization, good ability for reaction catalysis and electron transfer, and good biocompatibility. MNPs can be used alone and in combination with other classes of nanostructures. MNP-based sensors can lead to significant signal amplification, higher sensitivity, and great improvements in the detection and quantification of biomolecules and different ions. Some recent examples of biomolecular sensors using MNPs are given, and the effects of structure, shape, and other physical properties of noble MNPs and nanohybrids in biosensor performance are discussed.

Original languageEnglish
Pages (from-to)301-329
Number of pages29
JournalNanotechnology Reviews
Issue number3
Publication statusPublished - 27 Jun 2017
Externally publishedYes


  • biomolecule detection
  • colorometric
  • electrochemical
  • metal nanostructures
  • nanobiosensor
  • optical
  • piezoelectric

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Energy Engineering and Power Technology
  • Engineering (miscellaneous)
  • Process Chemistry and Technology


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