Nitrilium ions-synthesis and applications

Tom Van Dijk, J. Chris Slootweg, Koop Lammertsma

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)


Nitrilium ions have been well-established in organic chemistry for many decades, but recent developments show them to be far more versatile than hitherto recognized. They are known as stable salts, can be generated in situ, or are present as transient intermediates. We provide a succinct, but comprehensive review on the synthesis, stability, and reactivity of nitrilium ions as synthons for imines, their use in the synthesis of a large spectrum of heterocycles, and their reactions with transition metal complexes. By offering this overview, we aim for a renewed focus on readily accessible and simple to use nitrilium ions as valuable reagents for the synthesis of organic compounds.

Original languageEnglish
Pages (from-to)10134-10144
Number of pages11
JournalOrganic and Biomolecular Chemistry
Issue number48
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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