TY - JOUR
T1 - New Prenylated Isoflavonoids From Erythrina addisoniae With Anti-Neuroinflammatory Activity via Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells Pathway Suppression
AU - An, Jin Pyo
AU - Seong, Gi Hyeon
AU - Che, Yun Hui
AU - Ponce-Zea, Jorge Eduardo
AU - Mai, Van Hieu
AU - Ndinteh, Derek Tantoh
AU - Mbafor, Joseph Tanyi
AU - Oh, Won Keun
N1 - Publisher Copyright:
© 2026 Wiley-VHCA AG.
PY - 2026/1
Y1 - 2026/1
N2 - Recent investigations have identified prenylated isoflavonoids as major constituents of Erythrina addisoniae, yet their anti-neuroinflammatory potential remains unexplored. Through bioassay-guided isolation, two new prenylated isoflavonoids (1 and 2), along with nine known compounds (3–11), were characterized using spectroscopic methods. All isolates were tested for inhibitory effects on nitric oxide (NO) production in BV-2 microglial cells. Compounds 1, 6, 7, and 10 significantly reduced NO levels, with compounds 1 and 10 showing the strongest activity (IC50 values of 3.57 ± 1.22 and 0.69 ± 0.18 µM, respectively). Western blot analysis confirmed the downregulation of inducible NO synthase protein, and molecular docking analysis revealed that compound 10 interacts with nuclear factor kappa-light-chain-enhancer of activated B cells. These results highlight prenylated isoflavonoids from E. addisoniae as potential anti-neuroinflammatory agents.
AB - Recent investigations have identified prenylated isoflavonoids as major constituents of Erythrina addisoniae, yet their anti-neuroinflammatory potential remains unexplored. Through bioassay-guided isolation, two new prenylated isoflavonoids (1 and 2), along with nine known compounds (3–11), were characterized using spectroscopic methods. All isolates were tested for inhibitory effects on nitric oxide (NO) production in BV-2 microglial cells. Compounds 1, 6, 7, and 10 significantly reduced NO levels, with compounds 1 and 10 showing the strongest activity (IC50 values of 3.57 ± 1.22 and 0.69 ± 0.18 µM, respectively). Western blot analysis confirmed the downregulation of inducible NO synthase protein, and molecular docking analysis revealed that compound 10 interacts with nuclear factor kappa-light-chain-enhancer of activated B cells. These results highlight prenylated isoflavonoids from E. addisoniae as potential anti-neuroinflammatory agents.
KW - Erythrina addisoniae
KW - molecular docking analysis
KW - neuroinflammation
KW - prenylated isoflavonoid
UR - https://www.scopus.com/pages/publications/105026986515
U2 - 10.1002/cbdv.202503261
DO - 10.1002/cbdv.202503261
M3 - Article
C2 - 41503951
AN - SCOPUS:105026986515
SN - 1612-1872
VL - 23
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 1
M1 - e03261
ER -