TY - JOUR
T1 - Neutrophil mediated drug delivery for targeted glioblastoma therapy
T2 - A comprehensive review
AU - Hosseinalizadeh, Hamed
AU - Mahmoodpour, Mehrdad
AU - Razaghi Bahabadi, Zahra
AU - Hamblin, Michael R.
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/12
Y1 - 2022/12
N2 - Glioblastoma is the most common brain cancer in adults and presents a major challenge for targeted drug delivery due to the blood-brain barrier (BBB) and the highly infiltrative growth of the glioma cells into the brain. Cell-mediated drug-delivery systems have been proposed as a potential strategy to enhance the effects of drugs and reduce their side effects in the treatment of cancer. Neutrophils are the most abundant type of WBC in humans and can overcome impermeable barriers and transport drugs into inflamed sites such as tumors. Therefore, a promising approach for an innovative drug delivery system is the use of neutrophils as Trojan horses for drug delivery. However, compared to other leukocytes such as macrophages, little is known about how human neutrophils respond to and take up synthetic particles. In this review, we summarize the factors affecting the uptake of nanoparticles (NPs) by neutrophils, as well as recent advances and challenges related to the interaction between neutrophils and NPs, with particular emphasis on the interaction of magnetic mesoporous silica NPs, liposomes, albumin NPs, and PLGA NPs with neutrophils. Finally, the potential application of neutrophil-based drug delivery systems for the prevention of glioblastoma recurrence and also the potential application of neutrophil-mimicking nanoparticles (NM-NPs) in glioblastoma therapy are discussed.
AB - Glioblastoma is the most common brain cancer in adults and presents a major challenge for targeted drug delivery due to the blood-brain barrier (BBB) and the highly infiltrative growth of the glioma cells into the brain. Cell-mediated drug-delivery systems have been proposed as a potential strategy to enhance the effects of drugs and reduce their side effects in the treatment of cancer. Neutrophils are the most abundant type of WBC in humans and can overcome impermeable barriers and transport drugs into inflamed sites such as tumors. Therefore, a promising approach for an innovative drug delivery system is the use of neutrophils as Trojan horses for drug delivery. However, compared to other leukocytes such as macrophages, little is known about how human neutrophils respond to and take up synthetic particles. In this review, we summarize the factors affecting the uptake of nanoparticles (NPs) by neutrophils, as well as recent advances and challenges related to the interaction between neutrophils and NPs, with particular emphasis on the interaction of magnetic mesoporous silica NPs, liposomes, albumin NPs, and PLGA NPs with neutrophils. Finally, the potential application of neutrophil-based drug delivery systems for the prevention of glioblastoma recurrence and also the potential application of neutrophil-mimicking nanoparticles (NM-NPs) in glioblastoma therapy are discussed.
KW - Glioma
KW - Inflammation
KW - Nanoparticles
KW - Neutrophils
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85140990820&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2022.113841
DO - 10.1016/j.biopha.2022.113841
M3 - Review article
C2 - 36411657
AN - SCOPUS:85140990820
SN - 0753-3322
VL - 156
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 113841
ER -
