Neutral and cationic osmium(II)-arene metallodendrimers: Synthesis, characterisation and anticancer activity Metallodendrimers Special Issue

Preshendren Govender, Fabio Edafe, Banothile C.E. Makhubela, Paul J. Dyson, Bruno Therrien, Gregory S. Smith

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Two neutral and two cationic half-sandwich Os(II)-arene metallodendrimers, of general formula [DAB-PPI-{(η6-p-cym)Os((C7H 5NO)-κ2-N,O)Cl}n] and [DAB-PPI-{(η6-p-cym)Os((C6H5N 2)-κ2-N,N)Cl}n][PF6] n (where n = 4 (G1) or 8 (G2)) have been synthesised. In addition, two cationic half-sandwich Os(II)-arene metallodendrimers, containing PTA (1,3,5-triaza-7-phosphatricyclo[3.3.1.1.] decane), of general formula [DAB-PPI-{(η6-p-cym)Os((C7H5NO)- κ2-N,O)PTA}n][PF6]n are also reported. All complexes have been characterised using analytical (i.e. HR-ESI or EI mass spectrometry and elemental analysis) and spectroscopic (i.e. 1H, 13C{1H} NMR and infrared) methods. Model mononuclear analogues have been prepared and their molecular structures determined by single-crystal X-ray crystallography. The cytotoxicity of the complexes were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines and some display moderate activity.

Original languageEnglish
Pages (from-to)112-120
Number of pages9
JournalInorganica Chimica Acta
Volume409
Issue numberPART A
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Anticancer agent
  • Bioorganometallic chemistry
  • Dendrimer
  • Osmium-arene
  • Poly(propyleneimine)

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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