Abstract
Two neutral and two cationic half-sandwich Os(II)-arene metallodendrimers, of general formula [DAB-PPI-{(η6-p-cym)Os((C7H 5NO)-κ2-N,O)Cl}n] and [DAB-PPI-{(η6-p-cym)Os((C6H5N 2)-κ2-N,N)Cl}n][PF6] n (where n = 4 (G1) or 8 (G2)) have been synthesised. In addition, two cationic half-sandwich Os(II)-arene metallodendrimers, containing PTA (1,3,5-triaza-7-phosphatricyclo[3.3.1.1.] decane), of general formula [DAB-PPI-{(η6-p-cym)Os((C7H5NO)- κ2-N,O)PTA}n][PF6]n are also reported. All complexes have been characterised using analytical (i.e. HR-ESI or EI mass spectrometry and elemental analysis) and spectroscopic (i.e. 1H, 13C{1H} NMR and infrared) methods. Model mononuclear analogues have been prepared and their molecular structures determined by single-crystal X-ray crystallography. The cytotoxicity of the complexes were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines and some display moderate activity.
Original language | English |
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Pages (from-to) | 112-120 |
Number of pages | 9 |
Journal | Inorganica Chimica Acta |
Volume | 409 |
Issue number | PART A |
DOIs | |
Publication status | Published - 2014 |
Externally published | Yes |
Keywords
- Anticancer agent
- Bioorganometallic chemistry
- Dendrimer
- Osmium-arene
- Poly(propyleneimine)
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry
- Materials Chemistry