TY - JOUR
T1 - Natural deep eutectic solvent supported targeted solid-liquid polymer carrier for breast cancer therapy
AU - Sun, Xianfu
AU - Pradeepkumar, Periyakaruppan
AU - Rajendran, Naresh Kumar
AU - Shakila, Harshavardhan
AU - Houreld, Nicolette Nadene
AU - Al Farraj, Dunia A.
AU - Elnahas, Yousif M.
AU - Elumalai, Nandhakumar
AU - Rajan, Mariappan
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2020.
PY - 2020/10/7
Y1 - 2020/10/7
N2 - Solid-liquid nanocarriers (SLNs) are at the front of the rapidly emerging field of medicinal applications with a potential role in the delivery of bioactive agents. Here, we report a new SLN of natural deep eutectic solvent (NADES) and biotin-conjugated lysine-polyethylene glycol copolymer. The SLN system was analyzed for its functional groups, thermal stability, crystalline nature, particle size, and surface morphology through the instrumental analysis of FT-IR, TGA, XRD, DLS, SEM, and TEM. Encapsulation of PTX (paclitaxel) and 7-HC (7-hydroxycoumarin) with the SLN was carried out by dialysis, and UV-visible spectra evidenced the drug loading capacity and higher encapsulation efficiency obtained. The enhanced anticancer potential of PTX- and 7-HC-loaded SLN was assessedin vitro, and the system reduces the cell viability of MDA-MB-231 cells. The PTX- and 7-HC-loaded SLN system was investigated in a breast cancer-induced rat modelvia in vivostudies. It shows decreased lysosomal enzymes and increased levels of caspase to cure breast tumors. It very well may be reasoned that the designed PTX- and 7-HC-loaded SLN system has strong anticancer properties and exhibits potential for delivery of drug molecules in cancer treatment.
AB - Solid-liquid nanocarriers (SLNs) are at the front of the rapidly emerging field of medicinal applications with a potential role in the delivery of bioactive agents. Here, we report a new SLN of natural deep eutectic solvent (NADES) and biotin-conjugated lysine-polyethylene glycol copolymer. The SLN system was analyzed for its functional groups, thermal stability, crystalline nature, particle size, and surface morphology through the instrumental analysis of FT-IR, TGA, XRD, DLS, SEM, and TEM. Encapsulation of PTX (paclitaxel) and 7-HC (7-hydroxycoumarin) with the SLN was carried out by dialysis, and UV-visible spectra evidenced the drug loading capacity and higher encapsulation efficiency obtained. The enhanced anticancer potential of PTX- and 7-HC-loaded SLN was assessedin vitro, and the system reduces the cell viability of MDA-MB-231 cells. The PTX- and 7-HC-loaded SLN system was investigated in a breast cancer-induced rat modelvia in vivostudies. It shows decreased lysosomal enzymes and increased levels of caspase to cure breast tumors. It very well may be reasoned that the designed PTX- and 7-HC-loaded SLN system has strong anticancer properties and exhibits potential for delivery of drug molecules in cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=85093665224&partnerID=8YFLogxK
U2 - 10.1039/d0ra03790g
DO - 10.1039/d0ra03790g
M3 - Article
AN - SCOPUS:85093665224
SN - 2046-2069
VL - 10
SP - 36989
EP - 37004
JO - RSC Advances
JF - RSC Advances
IS - 61
ER -
