Nanotechnology in diagnosis and treatment of coronary artery disease

Mahdi Karimi; Hossein Zare; Amirala Bakhshian Nik; Narges Yazdani; Mohammad Hamrang; Elmira Mohamed; Parham Sahandi Zangabad; Seyed Masoud Moosavi Basri; Leila Bakhtiari; Michael R. Hamblin

doi:10.2217/nnm.16.3

Nanotechnology in diagnosis and treatment of coronary artery disease

Mahdi Karimi
, Hossein Zare
, Amirala Bakhshian Nik
, Narges Yazdani
, Mohammad Hamrang
, Elmira Mohamed
, Parham Sahandi Zangabad
, Seyed Masoud Moosavi Basri
, Leila Bakhtiari
, Michael R. Hamblin

Iran University of Medical Sciences
Iran University of Science and Technology
University of Tehran
Sharif University of Technology
Institute for Research for Fundamental Sciences
Shahid Beheshti University
Massachusetts General Hospital
Harvard University
Harvard-MIT Division of Health Sciences and Technology

Research output: Contribution to journal › Review article › peer-review

75 Citations (Scopus)

Abstract

Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.

Original language	English
Pages (from-to)	513-530
Number of pages	18
Journal	Nanomedicine
Volume	11
Issue number	5
DOIs	https://doi.org/10.2217/nnm.16.3
Publication status	Published - Mar 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

atherosclerosis
coronary artery disease
nanocarriers
nanotechnology
restenosis
stent coatings
vulnerable plaque

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Development

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10.2217/nnm.16.3

Cite this

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title = "Nanotechnology in diagnosis and treatment of coronary artery disease",

abstract = "Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.",

keywords = "atherosclerosis, coronary artery disease, nanocarriers, nanotechnology, restenosis, stent coatings, vulnerable plaque",

author = "Mahdi Karimi and Hossein Zare and \{Bakhshian Nik\}, Amirala and Narges Yazdani and Mohammad Hamrang and Elmira Mohamed and Zangabad, \{Parham Sahandi\} and Basri, \{Seyed Masoud Moosavi\} and Leila Bakhtiari and Hamblin, \{Michael R.\}",

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year = "2016",

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doi = "10.2217/nnm.16.3",

language = "English",

volume = "11",

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AU - Karimi, Mahdi

AU - Zare, Hossein

AU - Bakhshian Nik, Amirala

AU - Yazdani, Narges

AU - Hamrang, Mohammad

AU - Mohamed, Elmira

AU - Zangabad, Parham Sahandi

AU - Basri, Seyed Masoud Moosavi

AU - Bakhtiari, Leila

AU - Hamblin, Michael R.

PY - 2016/3

Y1 - 2016/3

N2 - Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.

AB - Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.

KW - atherosclerosis

KW - coronary artery disease

KW - nanocarriers

KW - nanotechnology

KW - restenosis

KW - stent coatings

KW - vulnerable plaque

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DO - 10.2217/nnm.16.3

M3 - Review article

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SN - 1743-5889

VL - 11

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EP - 530

JO - Nanomedicine

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ER -

Nanotechnology in diagnosis and treatment of coronary artery disease

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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