Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies

Akbar Hasanzadeh, Masoomeh Alamdaran, Sepideh Ahmadi, Helena Nourizadeh, Mohammad Aref Bagherzadeh, Mirza Ali Mofazzal Jahromi, Perikles Simon, Mahdi Karimi, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in early 2020 soon led to the global pandemic of Coronavirus Disease 2019 (COVID-19). Since then, the clinical and scientific communities have been closely collaborating to develop effective strategies for controlling the ongoing pandemic. The game-changing fields of recent years, nanotechnology and nanomedicine have the potential to not only design new approaches, but also to improve existing methods for the fight against COVID-19. Nanomaterials can be used in the development of highly efficient, reusable personal protective equipment, and antiviral nano-coatings in public settings could prevent the spread of SARS-CoV-2. Smart nanocarriers have accelerated the design of several therapeutic, prophylactic, or immune-mediated approaches against COVID-19. Some nanovaccines have even entered Phase IΙ/IIΙ clinical trials. Several rapid and cost-effective COVID-19 diagnostic techniques have also been devised based on nanobiosensors, lab-on-a-chip systems, or nanopore technology. Here, we provide an overview of the emerging role of nanotechnology in the prevention, diagnosis, and treatment of COVID-19.

Original languageEnglish
Pages (from-to)354-374
Number of pages21
JournalJournal of Controlled Release
Publication statusPublished - 10 Aug 2021
Externally publishedYes


  • COVID-19
  • Diagnosis
  • Nanotechnology
  • Nanovaccine
  • SARS-CoV-2

ASJC Scopus subject areas

  • Pharmaceutical Science


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