TY - CHAP
T1 - Nanoscale Formulation Techniques for Biotherapeutics
AU - Motsoene, Fezile
AU - Singaravelu, Sivakumar
AU - Abrahamse, Heidi
AU - Dhilip Kumar, Sathish Sundar
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
PY - 2025
Y1 - 2025
N2 - The development of nanoscale formulations (NFs) in biotherapeutics has revolutionised drug delivery, diagnostics, and treatment strategies, resulting in a new era of precision medicine. NFs were developed to overcome the limitations of conventional drug delivery systems and navigate biological barriers effectively. This chapter highlights the crucial role of NFs in developing personalised and effective therapies. Additionally, the chapter provides a thorough understanding of the synthetic methods, characterisations, and the application of various NFS in biotherapeutics. Moreover, the integration of NFs within various therapeutic platforms, including antibody conjugation, protein fusion, gene expression and monoclonal-antibody delivery, are discussed within this chapter. Subsequently, the benefits, limitations and enhancement strategies associated with NFs drug bioavailability, targeting specificity, stability, and the potential for controlled release will be discussed The final section discusses emerging trends, future perspectives, and key recommendations for advancing the field of nanomedicine, spotlighting its potential to address limitations in current therapeutic approaches.
AB - The development of nanoscale formulations (NFs) in biotherapeutics has revolutionised drug delivery, diagnostics, and treatment strategies, resulting in a new era of precision medicine. NFs were developed to overcome the limitations of conventional drug delivery systems and navigate biological barriers effectively. This chapter highlights the crucial role of NFs in developing personalised and effective therapies. Additionally, the chapter provides a thorough understanding of the synthetic methods, characterisations, and the application of various NFS in biotherapeutics. Moreover, the integration of NFs within various therapeutic platforms, including antibody conjugation, protein fusion, gene expression and monoclonal-antibody delivery, are discussed within this chapter. Subsequently, the benefits, limitations and enhancement strategies associated with NFs drug bioavailability, targeting specificity, stability, and the potential for controlled release will be discussed The final section discusses emerging trends, future perspectives, and key recommendations for advancing the field of nanomedicine, spotlighting its potential to address limitations in current therapeutic approaches.
KW - Bioavailability
KW - Biotherapeutics
KW - Drug delivery
KW - Nanomedicine
KW - Nanoscale formulations
UR - https://www.scopus.com/pages/publications/105017996696
U2 - 10.1007/978-3-032-00796-4_8
DO - 10.1007/978-3-032-00796-4_8
M3 - Chapter
AN - SCOPUS:105017996696
T3 - Progress in Drug Research
SP - 215
EP - 251
BT - Progress in Drug Research
PB - Springer Science and Business Media Deutschland GmbH
ER -