Nanoparticle-based therapeutic strategies in prostate cancer suppression

Samaneh Adelian, Amin Soltani, Michael R. Hamblin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The use of a combination of cytotoxic medications and hormone therapy/ gene therapy has been widely acknowledged as an established approach to treating metastatic prostate cancer. Nevertheless, the effectiveness of this approach is limited by the inadequate ability of the chemotherapy to reach tumor sites, leading to a higher occurrence of collateral damage and multidrug resistance (MDR). The use of nanovectorization techniques has developed into a successful method for achieving excellent therapeutic results. This technology has the potential to increase the targeted and less hazardous targeting mechanisms for anticancer action, as well as provide diagnostic imaging using theragnostic. While research on nanomedicine is prevalent in several cancer types, there has been less emphasis on its use specifcally in prostate cancer. This study offers a comprehensive understanding of the fundamental concepts behind nanotherapeutics and nanotheranostics, as well as their potential clinical implications in the treatment of prostate cancer. This study focuses on the clinical and preclinical data on the use of nanovectors in prostate cancer therapy techniques. Specifcally, we examine the possibilities and prospects of using homing nanovectorization in these tactics.

Original languageEnglish
Title of host publicationProstate Cancer
Subtitle of host publicationMolecular Events and Therapeutic Modalities
PublisherSpringer Nature
Pages273-291
Number of pages19
ISBN (Electronic)9789819746125
ISBN (Print)9789819746118
DOIs
Publication statusPublished - 26 Nov 2024

Keywords

  • Liposomal nanoparticles
  • Multidrug resistance (MDR)
  • Nanotheranostics
  • Non-AR therapeutic targets
  • Permeability and retention (EPR) effect

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology

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