Nano-based delivery systems for berberine: A modern anti-cancer herbal medicine

Hossein Majidzadeh, Mostafa Araj-Khodaei, Maryam Ghaffari, Mohammadali Torbati, Jafar Ezzati Nazhad Dolatabadi, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)

Abstract

Berberine (BBR) is an isoquinoline alkaloid belonging to the structural class of protoberberines. BBR has been used in traditional medicine to treat diseases, such as type 2 diabetes and hypercholesterolemia. BBR inhibits cancer cell growth and induces apoptosis. However, BBR has significant drawbacks as a chemotherapeutic agent, including poor solubility, and induction of drug resistance, limiting its application in chemotherapy. Hence, combination therapy could not only deal with the problems related to single-agent chemotherapy but could also improve the therapeutic index of anticancer drugs. Co-administration of drugs may show pharmaceutical incompatibility due to conflicting physicochemical features. BBR can be used in nanoparticle-based single drug delivery, and in co-delivery systems designed to accommodate drugs and deliver them simultaneously into cancer cells. In this review, we will summarize the use of BBR, including BBR as a single chemotherapeutic agent and the combination of BBR with traditional anti-cancer drugs or herbal medicines in nanoparticle-based delivery systems.

Original languageEnglish
Article number111188
JournalColloids and Surfaces B: Biointerfaces
Volume194
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Berberine
  • Cancer therapy
  • Co-delivery systems
  • Herbal medicines
  • Nanoparticles

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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