Multifunctional lipid-based nanoparticles for wound healing and antibacterial applications: A review

Fezile Motsoene, Heidi Abrahamse, Sathish Sundar Dhilip Kumar

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Wound healing primarily involves preventing severe infections, accelerating healing, and reducing pain and scarring. Therefore, the multifunctional application of lipid-based nanoparticles (LBNs) has received considerable attention in drug discovery due to their solid or liquid lipid core, which increases their ability to provide prolonged drug release, reduce treatment costs, and improve patient compliance. LBNs have also been used in medical and cosmetic practices and formulated for various products based on skin type, disease conditions, administration product costs, efficiency, stability, and toxicity; therefore, understanding their interaction with biological systems is very important. Therefore, it is necessary to perform an in-depth analysis of the results from a comprehensive characterization process to produce lipid-based drug delivery systems with desired properties. This review will provide detailed information on the different types of LBNs, their formulation methods, characterisation, antimicrobial activity, and application in various wound models (both in vitro and in vivo studies). Also, the clinical and commercial applications of LBNs are summarized.

Original languageEnglish
Article number103002
JournalAdvances in Colloid and Interface Science
Volume321
DOIs
Publication statusPublished - Nov 2023

Keywords

  • Solid lipid nanoparticles
  • antibacterial activity
  • biomaterial
  • drug delivery
  • liposomes
  • polymer lipid nanoparticles
  • wound healing

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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