TY - JOUR
T1 - Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line
AU - Aliyu, Muhammad
AU - Odunola, Oyeronke A.
AU - Farooq, Ahsana D.
AU - Rasheed, Huma
AU - Mesaik, Ahmed M.
AU - Choudhary, Muhammad I.
AU - Channa, Iffat S.
AU - Khan, Salman A.
AU - Erukainure, Ochuko L.
PY - 2013
Y1 - 2013
N2 - Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.
AB - Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.
UR - https://www.scopus.com/pages/publications/84874591256
U2 - 10.1080/01635581.2013.756920
DO - 10.1080/01635581.2013.756920
M3 - Article
C2 - 23441617
AN - SCOPUS:84874591256
SN - 0163-5581
VL - 65
SP - 296
EP - 304
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 2
ER -
