Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line

Muhammad Aliyu; Oyeronke A. Odunola; Ahsana D. Farooq; Huma Rasheed; Ahmed M. Mesaik; Muhammad I. Choudhary; Iffat S. Channa; Salman A. Khan; Ochuko L. Erukainure

doi:10.1080/01635581.2013.756920

Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line

Muhammad Aliyu
, Oyeronke A. Odunola
, Ahsana D. Farooq
, Huma Rasheed
, Ahmed M. Mesaik
, Muhammad I. Choudhary
, Iffat S. Channa
, Salman A. Khan
, Ochuko L. Erukainure

University of Ibadan
University of Karachi

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.

Original language	English
Pages (from-to)	296-304
Number of pages	9
Journal	Nutrition and Cancer
Volume	65
Issue number	2
DOIs	https://doi.org/10.1080/01635581.2013.756920
Publication status	Published - 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Medicine (miscellaneous)
Oncology
Nutrition and Dietetics
Cancer Research

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10.1080/01635581.2013.756920

Cite this

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title = "Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line",

abstract = "Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.",

author = "Muhammad Aliyu and Odunola, \{Oyeronke A.\} and Farooq, \{Ahsana D.\} and Huma Rasheed and Mesaik, \{Ahmed M.\} and Choudhary, \{Muhammad I.\} and Channa, \{Iffat S.\} and Khan, \{Salman A.\} and Erukainure, \{Ochuko L.\}",

year = "2013",

doi = "10.1080/01635581.2013.756920",

language = "English",

volume = "65",

pages = "296--304",

journal = "Nutrition and Cancer",

issn = "0163-5581",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line

AU - Aliyu, Muhammad

AU - Odunola, Oyeronke A.

AU - Farooq, Ahsana D.

AU - Rasheed, Huma

AU - Mesaik, Ahmed M.

AU - Choudhary, Muhammad I.

AU - Channa, Iffat S.

AU - Khan, Salman A.

AU - Erukainure, Ochuko L.

PY - 2013

Y1 - 2013

N2 - Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.

AB - Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.

UR - https://www.scopus.com/pages/publications/84874591256

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DO - 10.1080/01635581.2013.756920

M3 - Article

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AN - SCOPUS:84874591256

SN - 0163-5581

VL - 65

SP - 296

EP - 304

JO - Nutrition and Cancer

JF - Nutrition and Cancer

IS - 2

ER -

Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line

Abstract

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