Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation

Kenichiro Koshiyama; Tetsuya Kodama; Michael R. Hamblin; Apostolos G. Doukas; Takeru Yano; Shigeo Fujikawa

doi:10.1063/1.1901611

Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation

Kenichiro Koshiyama
, Tetsuya Kodama
, Michael R. Hamblin
, Apostolos G. Doukas
, Takeru Yano
, Shigeo Fujikawa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Cell permeabilization by shock waves may have application in gene therapy and anticancer drug delivery. In the present study we performed direct molecular dynamic (MD) simulation of the interaction of a single shock wave with a cell membrane to investigate the mechanism of the cell permeabilization. The shock wave was characterized by an impulse that was expressed with a velocity determined by the change in the momentum. The cell membrane was designed as a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer placed between two layers of water molecules. The MD simulation determined the relationship between water penetration into the bilayer, the order parameter, the fluidity of each lipid molecule, and the intensity of impulse. These structural changes in the bilayer may be an important factor in the use of shock waves to produce transient membrane permeability.

Original language	English
Title of host publication	4th International Symposium on Therapeutic Ultrasound
Pages	104-106
Number of pages	3
DOIs	https://doi.org/10.1063/1.1901611
Publication status	Published - 28 Mar 2005
Externally published	Yes
Event	4th International Symposium on Therapeutic Ultrasound - Kyoto, Japan Duration: 18 Sept 2004 → 20 Sept 2004

Publication series

Name	AIP Conference Proceedings
Volume	754
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Symposium on Therapeutic Ultrasound
Country/Territory	Japan
City	Kyoto
Period	18/09/04 → 20/09/04

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Physics and Astronomy

Access to Document

10.1063/1.1901611

Cite this

@inproceedings{834607d49e1d451eb57babc546be37b8,

title = "Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation",

abstract = "Cell permeabilization by shock waves may have application in gene therapy and anticancer drug delivery. In the present study we performed direct molecular dynamic (MD) simulation of the interaction of a single shock wave with a cell membrane to investigate the mechanism of the cell permeabilization. The shock wave was characterized by an impulse that was expressed with a velocity determined by the change in the momentum. The cell membrane was designed as a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer placed between two layers of water molecules. The MD simulation determined the relationship between water penetration into the bilayer, the order parameter, the fluidity of each lipid molecule, and the intensity of impulse. These structural changes in the bilayer may be an important factor in the use of shock waves to produce transient membrane permeability.",

author = "Kenichiro Koshiyama and Tetsuya Kodama and Hamblin, \{Michael R.\} and Doukas, \{Apostolos G.\} and Takeru Yano and Shigeo Fujikawa",

year = "2005",

month = mar,

day = "28",

doi = "10.1063/1.1901611",

language = "English",

isbn = "0735402396",

series = "AIP Conference Proceedings",

pages = "104--106",

booktitle = "4th International Symposium on Therapeutic Ultrasound",

note = "4th International Symposium on Therapeutic Ultrasound ; Conference date: 18-09-2004 Through 20-09-2004",

}

Koshiyama, K, Kodama, T, Hamblin, MR, Doukas, AG, Yano, T & Fujikawa, S 2005, Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation. in 4th International Symposium on Therapeutic Ultrasound. AIP Conference Proceedings, vol. 754, pp. 104-106, 4th International Symposium on Therapeutic Ultrasound, Kyoto, Japan, 18/09/04. https://doi.org/10.1063/1.1901611

Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation. / Koshiyama, Kenichiro; Kodama, Tetsuya; Hamblin, Michael R. et al.
4th International Symposium on Therapeutic Ultrasound. 2005. p. 104-106 (AIP Conference Proceedings; Vol. 754).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation

AU - Koshiyama, Kenichiro

AU - Kodama, Tetsuya

AU - Hamblin, Michael R.

AU - Doukas, Apostolos G.

AU - Yano, Takeru

AU - Fujikawa, Shigeo

PY - 2005/3/28

Y1 - 2005/3/28

N2 - Cell permeabilization by shock waves may have application in gene therapy and anticancer drug delivery. In the present study we performed direct molecular dynamic (MD) simulation of the interaction of a single shock wave with a cell membrane to investigate the mechanism of the cell permeabilization. The shock wave was characterized by an impulse that was expressed with a velocity determined by the change in the momentum. The cell membrane was designed as a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer placed between two layers of water molecules. The MD simulation determined the relationship between water penetration into the bilayer, the order parameter, the fluidity of each lipid molecule, and the intensity of impulse. These structural changes in the bilayer may be an important factor in the use of shock waves to produce transient membrane permeability.

AB - Cell permeabilization by shock waves may have application in gene therapy and anticancer drug delivery. In the present study we performed direct molecular dynamic (MD) simulation of the interaction of a single shock wave with a cell membrane to investigate the mechanism of the cell permeabilization. The shock wave was characterized by an impulse that was expressed with a velocity determined by the change in the momentum. The cell membrane was designed as a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer placed between two layers of water molecules. The MD simulation determined the relationship between water penetration into the bilayer, the order parameter, the fluidity of each lipid molecule, and the intensity of impulse. These structural changes in the bilayer may be an important factor in the use of shock waves to produce transient membrane permeability.

UR - https://www.scopus.com/pages/publications/33748568823

U2 - 10.1063/1.1901611

DO - 10.1063/1.1901611

M3 - Conference contribution

AN - SCOPUS:33748568823

SN - 0735402396

SN - 9780735402393

T3 - AIP Conference Proceedings

SP - 104

EP - 106

BT - 4th International Symposium on Therapeutic Ultrasound

T2 - 4th International Symposium on Therapeutic Ultrasound

Y2 - 18 September 2004 through 20 September 2004

ER -

Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation

Abstract

Publication series

Conference

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this