Molecular Communication Model of Signal Propagation in Confined Microenvironment for Targeted Drug Delivery to Organelles

To develop or analyze a molecular communication (MC) system, there is the need to model the communication channel through which the molecular signal diffuse, from the transmitter to the receiver. Many models for the diffusion-based MC channel have been proposed in the literature for evaluating the performance of MC systems. Most of the contemporary works assume, and rightly so for some scenarios, that the MC channels under consideration have infinite boundaries. However, this assumption becomes invalid in bounded domains such as the interiors of natural cells and artificially synthesized nanosystems. In this paper, we present the channel model of molecular propagation in a confined microenvironment. Using the developed channel model, we present numerical results that explore the impact of channel dimension on the targeted delivery of drugs for organelle targeting. Results indicate that dimension influences the drug molecule concentration delivered to an organelle by a nanocarrier that releases drug molecules after being internalized in the cell.