Modelling multiple dosing with drug holiday in antiretroviral treatment on HIV-1 infection

Sutimin, Nuning Nuraini, Faraimunashe Chirove, Lisyani Budipradigda Suromo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A within-host mathematical model to describe the dynamics of target cells and viral load in early HIV-1 infection was developed, which incorporates a combination of RTI and PI treatments by using a pharmacokinetics model. The local stability of uninfected steady state for the model was determined using an alternative threshold. The pharmacokinetics model was employed to estimate drug efficacy in multiple drug dosing. The effect of periodic drug efficacy of pharmacokinetic type on outcome of HIV-1 infection was explored under various treatment interruptions. The effectiveness of treatment interruption was determined according to the time period of the drug holidays. The results showed that long drug holidays lead to therapy failure. Under interruption of treatments combining RTI and PI therapy, effectiveness of the treatment requires a short duration of the drug holiday.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalJournal of Mathematical and Fundamental Sciences
Issue number1
Publication statusPublished - 2017
Externally publishedYes


  • CD4T cells
  • Drug holiday
  • HIV-1
  • Langerhans
  • Pharmacokinetics

ASJC Scopus subject areas

  • General Chemistry
  • General Mathematics
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • Multidisciplinary
  • General Physics and Astronomy
  • General Earth and Planetary Sciences


Dive into the research topics of 'Modelling multiple dosing with drug holiday in antiretroviral treatment on HIV-1 infection'. Together they form a unique fingerprint.

Cite this