Modeling the transmission of Buruli ulcer in fluctuating environments

Belthasara Assan, Farai Nyabadza, Pietro Landi, Cang Hui

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The transmission dynamics of Buruli ulcer (BU) largely depends on environmental changes. In this paper a deterministic model for the transmission of BU in fluctuating environments is proposed. The model incorporates periodicity in the disease transmission pathways and the Mycobacterium ulcerans density that are thought to vary seasonally. Two reproduction numbers, the time-averaged reproduction number [R0] and the basic reproduction number R0, are determined and compared. It is shown that the time-averaged reproduction underestimates the number of infections. Numerical simulations confirmed that if R0 > 1 the infection is sustained seasonally. The model outcome suggests that environmental fluctuations should be taken into consideration in designing policies aimed at BU control and management.

Original languageEnglish
Article number1750063
JournalInternational Journal of Biomathematics
Issue number5
Publication statusPublished - 1 Jul 2017
Externally publishedYes


  • Buruli ulcer
  • basic reproduction number
  • extinction
  • persistence
  • time-averaged reproduction number

ASJC Scopus subject areas

  • Modeling and Simulation
  • Applied Mathematics


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