Modeling: Process optimization for design, engineering, and fabrication of biopolymer in situ–forming hydrogels

In recent years, biopolymer in situ-forming hydrogels have emerged as promising materials in various biomedical and pharmaceutical applications due to their biocompatibility and controlled drug delivery capabilities. This chapter provides a concise overview of the critical role of modeling in optimizing the process for designing, engineering, and fabricating these hydrogels. Through computational simulations and mathematical modeling, researchers can predict and fine-tune key parameters such as polymer concentration, cross-linking kinetics, and environmental conditions to achieve desired hydrogel properties. This approach not only enhances the efficiency of hydrogel production but also ensures the precise control of drug release rates, mechanical properties, and biodegradability. The integration of modeling techniques into the development of biopolymer in situ-forming hydrogels represents a significant advancement in tailoring these materials for a wide range of therapeutic applications, from tissue engineering to drug delivery systems. This chapter highlights the importance of interdisciplinary efforts between researchers in materials science, engineering, and biomedicine to harness the full potential of these innovative biomaterials through computational simulations and mathematical modeling.