MiRNAs derived from cancer-associated fibroblasts in colorectal cancer

Amir Savardashtaki; Zahra Shabaninejad; Ahmad Movahedpour; Roxana Sahebnasagh; Hamed Mirzaei; Michael R. Hamblin

doi:10.2217/epi-2019-0110

MiRNAs derived from cancer-associated fibroblasts in colorectal cancer

Amir Savardashtaki, Zahra Shabaninejad, Ahmad Movahedpour, Roxana Sahebnasagh, Hamed Mirzaei, Michael R. Hamblin

Research output: Contribution to journal › Review article › peer-review

62 Citations (Scopus)

Abstract

Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs). CAFs can promote neoplastic angiogenesis and tumor development in CRC. Mounting evidence suggests that many miRNAs are overexpressed (miR-21, miR-329, miR-181a, miR-199a, miR-382 and miR-215) in CRC CAFs, and these miRNAs can influence the spread, invasiveness and chemoresistance in neighboring tumor cells via paracrine signaling. Herein, we summarize the pathogenic roles of miRNAs and CAFs in CRC. Moreover, for first time, we highlight the miRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis.

Original language	English
Pages (from-to)	1627-1645
Number of pages	19
Journal	Epigenomics
Volume	11
Issue number	14
DOIs	https://doi.org/10.2217/epi-2019-0110
Publication status	Published - Nov 2019
Externally published	Yes

Keywords

cancer-associated fibroblasts
colorectal cancer
exosomes
metastasis
miRNAs
normal fibroblasts
oncogenes
tumor-suppressor genes

ASJC Scopus subject areas

Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/epi-2019-0110

Cite this

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title = "MiRNAs derived from cancer-associated fibroblasts in colorectal cancer",

abstract = "Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs). CAFs can promote neoplastic angiogenesis and tumor development in CRC. Mounting evidence suggests that many miRNAs are overexpressed (miR-21, miR-329, miR-181a, miR-199a, miR-382 and miR-215) in CRC CAFs, and these miRNAs can influence the spread, invasiveness and chemoresistance in neighboring tumor cells via paracrine signaling. Herein, we summarize the pathogenic roles of miRNAs and CAFs in CRC. Moreover, for first time, we highlight the miRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis.",

keywords = "cancer-associated fibroblasts, colorectal cancer, exosomes, metastasis, miRNAs, normal fibroblasts, oncogenes, tumor-suppressor genes",

author = "Amir Savardashtaki and Zahra Shabaninejad and Ahmad Movahedpour and Roxana Sahebnasagh and Hamed Mirzaei and Hamblin, {Michael R.}",

note = "Publisher Copyright: {\textcopyright} 2019 Future Medicine Ltd.",

year = "2019",

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doi = "10.2217/epi-2019-0110",

language = "English",

volume = "11",

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T1 - MiRNAs derived from cancer-associated fibroblasts in colorectal cancer

AU - Savardashtaki, Amir

AU - Shabaninejad, Zahra

AU - Movahedpour, Ahmad

AU - Sahebnasagh, Roxana

AU - Mirzaei, Hamed

AU - Hamblin, Michael R.

PY - 2019/11

Y1 - 2019/11

N2 - Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs). CAFs can promote neoplastic angiogenesis and tumor development in CRC. Mounting evidence suggests that many miRNAs are overexpressed (miR-21, miR-329, miR-181a, miR-199a, miR-382 and miR-215) in CRC CAFs, and these miRNAs can influence the spread, invasiveness and chemoresistance in neighboring tumor cells via paracrine signaling. Herein, we summarize the pathogenic roles of miRNAs and CAFs in CRC. Moreover, for first time, we highlight the miRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis.

AB - Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs). CAFs can promote neoplastic angiogenesis and tumor development in CRC. Mounting evidence suggests that many miRNAs are overexpressed (miR-21, miR-329, miR-181a, miR-199a, miR-382 and miR-215) in CRC CAFs, and these miRNAs can influence the spread, invasiveness and chemoresistance in neighboring tumor cells via paracrine signaling. Herein, we summarize the pathogenic roles of miRNAs and CAFs in CRC. Moreover, for first time, we highlight the miRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis.

KW - cancer-associated fibroblasts

KW - colorectal cancer

KW - exosomes

KW - metastasis

KW - miRNAs

KW - normal fibroblasts

KW - oncogenes

KW - tumor-suppressor genes

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U2 - 10.2217/epi-2019-0110

DO - 10.2217/epi-2019-0110

M3 - Review article

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AN - SCOPUS:85075090826

SN - 1750-1911

VL - 11

SP - 1627

EP - 1645

JO - Epigenomics

JF - Epigenomics

IS - 14

ER -

MiRNAs derived from cancer-associated fibroblasts in colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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