Microwave-assisted synthesis, characterization and in vitro biomedical applications of Hibiscus rosa-sinensis Linn.-mediated carbon quantum dots

Shweta Yalshetti, Bothe Thokchom, Santosh Mallikarjun Bhavi, Sapam Riches Singh, Sneha R. Patil, B. P. Harini, Mika Sillanpää, J. G. Manjunatha, B. S. Srinath, Ramesh Babu Yarajarla

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years, carbon quantum dots (CQDs) have garnered considerable attention as a promising material for biomedical applications because of their unique optical and biological properties. In this study, CQDs were derived from the leaves of Hibiscus rosa-sinensis Linn. via microwave-assisted technique and characterized using different techniques such as ultraviolet–visible, Fourier transform infrared, fluorescence spectrometry, X-ray diffraction, dynamic light scattering, transmission electron microscopy and energy-dispersive X-ray spectroscopy. Subsequently, their potential for biomedical applications was investigated through in vitro assays assessing scratch healing, anti-inflammatory, antibacterial, and cytotoxicity properties. It was found that the CQDs were fluorescent, polycrystalline, quasi-spherical, ~ 12 nm in size with presence of –OH and –COOH groups on their negatively charged surfaces, and demonstrated good anti-inflammatory by inhibiting protein denaturation, cyclooxygenase-2 and regulating inflammatory cytokines. The CQDs also exhibited antimicrobial activity against Klebsiella pneumoniae and Bacillus cereus, good biocompatibility, along with excellent promotion of cell proliferation in vitro, indicating their potential as a anti-inflammatory and wound healing material. The properties were more enhanced than their precursor, H. rosa-sinensis leaf extract. Hence, the CQDs synthesized from the leaves of H. rosa-sinensis can serve as a potential biomedical agent.

Original languageEnglish
Article number9915
JournalScientific Reports
Volume14
Issue number1
DOIs
Publication statusPublished - Dec 2024
Externally publishedYes

Keywords

  • Anti-inflammatory
  • Antibacterial
  • Carbon quantum dots (CQDs)
  • Hibiscus rosa-sinensis
  • Wound healing

ASJC Scopus subject areas

  • Multidisciplinary

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