TY - JOUR
T1 - MicroRNAs, long non-coding RNAs, and circular RNAs and gynecological cancers
T2 - focus on metastasis
AU - Rezaee, Aryan
AU - Ahmadpour, Sara
AU - Jafari, Ameneh
AU - Aghili, Sarehnaz
AU - Zadeh, Seyed Saeed Tamehri
AU - Rajabi, Ali
AU - Raisi, Arash
AU - Hamblin, Michael R.
AU - Mahjoubin-Tehran, Maryam
AU - Derakhshan, Marzieh
N1 - Publisher Copyright:
Copyright © 2023 Rezaee, Ahmadpour, Jafari, Aghili, Zadeh, Rajabi, Raisi, Hamblin, Mahjoubin-Tehran and Derakhshan.
PY - 2023
Y1 - 2023
N2 - Gynecologic cancer is a significant cause of death in women worldwide, with cervical cancer, ovarian cancer, and endometrial cancer being among the most well-known types. The initiation and progression of gynecologic cancers involve a variety of biological functions, including angiogenesis and metastasis—given that death mostly occurs from metastatic tumors that have invaded the surrounding tissues. Therefore, understanding the molecular pathways underlying gynecologic cancer metastasis is critical for enhancing patient survival and outcomes. Recent research has revealed the contribution of numerous non-coding RNAs (ncRNAs) to metastasis and invasion of gynecologic cancer by affecting specific cellular pathways. This review focuses on three types of gynecologic cancer (ovarian, endometrial, and cervical) and three kinds of ncRNAs (long non-coding RNAs, microRNAs, and circular RNAs). We summarize the detailed role of non-coding RNAs in the different pathways and molecular interactions involved in the invasion and metastasis of these cancers.
AB - Gynecologic cancer is a significant cause of death in women worldwide, with cervical cancer, ovarian cancer, and endometrial cancer being among the most well-known types. The initiation and progression of gynecologic cancers involve a variety of biological functions, including angiogenesis and metastasis—given that death mostly occurs from metastatic tumors that have invaded the surrounding tissues. Therefore, understanding the molecular pathways underlying gynecologic cancer metastasis is critical for enhancing patient survival and outcomes. Recent research has revealed the contribution of numerous non-coding RNAs (ncRNAs) to metastasis and invasion of gynecologic cancer by affecting specific cellular pathways. This review focuses on three types of gynecologic cancer (ovarian, endometrial, and cervical) and three kinds of ncRNAs (long non-coding RNAs, microRNAs, and circular RNAs). We summarize the detailed role of non-coding RNAs in the different pathways and molecular interactions involved in the invasion and metastasis of these cancers.
KW - circular RNAs
KW - gynecological cancer
KW - invasion
KW - metastasis
KW - microRNAs: long non-coding RNAs
UR - http://www.scopus.com/inward/record.url?scp=85174638294&partnerID=8YFLogxK
U2 - 10.3389/fonc.2023.1215194
DO - 10.3389/fonc.2023.1215194
M3 - Review article
AN - SCOPUS:85174638294
SN - 2234-943X
VL - 13
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1215194
ER -
