MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy

Amir Hossein Mohammadi, Seyedvahid Seyedmoalemi, Mahsa Moghanlou, Seyed Amirreza Akhlagh, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Ameneh Jafari, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Synaptic plasticity is the ability of synapses to weaken or strengthen over time, in response to changes in the activity of the neurons. It is orchestrated by a variety of genes, proteins, and external and internal factors, especially epigenetic factors. MicroRNAs (miRNAs) are well-acknowledged epigenetic modulators that regulate the translation and degradation of target genes in the nervous system. Increasing evidence has suggested that a number of miRNAs play important roles in modulating various aspects of synaptic plasticity. The deregulation of miRNAs could be associated with pathological alterations in synaptic plasticity, which could lead to different CNS-related diseases. Herein, we provide an update on the role of miRNAs in governing synaptic plasticity. In addition, we also summarize recent researches on the role of miRNAs in drug addiction, and their targets and mechanism of action. Understanding of the way in which miRNAs contribute to synaptic plasticity provides rational clues in establishing the novel biomarkers and new therapeutic strategies for the diagnosis and treatment of plasticity-related diseases and drug addiction.

Original languageEnglish
Pages (from-to)5084-5102
Number of pages19
JournalMolecular Neurobiology
Volume59
Issue number8
DOIs
Publication statusPublished - Aug 2022

Keywords

  • Drug addiction
  • Epigenetic regulation
  • MicroRNAs
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Neurology
  • Cellular and Molecular Neuroscience

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