TY - JOUR
T1 - MicroRNA let-7 and viral infections
T2 - focus on mechanisms of action
AU - Letafati, Arash
AU - Najafi, Sajad
AU - Mottahedi, Mehran
AU - Karimzadeh, Mohammad
AU - Shahini, Ali
AU - Garousi, Setareh
AU - Abbasi-Kolli, Mohammad
AU - Sadri Nahand, Javid
AU - Tamehri Zadeh, Seyed Saeed
AU - Hamblin, Michael R.
AU - Rahimian, Neda
AU - Taghizadieh, Mohammad
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense mechanisms. In particular, miRNA let-7 functions as an essential regulator of the function and differentiation of both innate and adaptive immune cells. Let-7 is involved in several human diseases, including cancer and viral infections. Several viral infections have found ways to dysregulate the expression of miRNAs. Extracellular vesicles (EV) are membrane-bound lipid structures released from many types of human cells that can transport proteins, lipids, mRNAs, and miRNAs, including let-7. After their release, EVs are taken up by the recipient cells and their contents released into the cytoplasm. Let-7-loaded EVs have been suggested to affect cellular pathways and biological targets in the recipient cells, and can modulate viral replication, the host antiviral response, and the action of cancer-related viruses. In the present review, we summarize the available knowledge concerning the expression of let-7 family members, functions, target genes, and mechanistic involvement in viral pathogenesis and host defense. This may provide insight into the development of new therapeutic strategies to manage viral infections.
AB - MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense mechanisms. In particular, miRNA let-7 functions as an essential regulator of the function and differentiation of both innate and adaptive immune cells. Let-7 is involved in several human diseases, including cancer and viral infections. Several viral infections have found ways to dysregulate the expression of miRNAs. Extracellular vesicles (EV) are membrane-bound lipid structures released from many types of human cells that can transport proteins, lipids, mRNAs, and miRNAs, including let-7. After their release, EVs are taken up by the recipient cells and their contents released into the cytoplasm. Let-7-loaded EVs have been suggested to affect cellular pathways and biological targets in the recipient cells, and can modulate viral replication, the host antiviral response, and the action of cancer-related viruses. In the present review, we summarize the available knowledge concerning the expression of let-7 family members, functions, target genes, and mechanistic involvement in viral pathogenesis and host defense. This may provide insight into the development of new therapeutic strategies to manage viral infections.
KW - Let-7
KW - MicroRNAs
KW - Regulatory role
KW - Viral infections
UR - http://www.scopus.com/inward/record.url?scp=85124611903&partnerID=8YFLogxK
U2 - 10.1186/s11658-022-00317-9
DO - 10.1186/s11658-022-00317-9
M3 - Review article
C2 - 35164678
AN - SCOPUS:85124611903
SN - 1425-8153
VL - 27
JO - Cellular and Molecular Biology Letters
JF - Cellular and Molecular Biology Letters
IS - 1
M1 - 14
ER -