MicroRNA-155 and antiviral immune responses

Abdollah Jafarzadeh, Alma Naseri, Layla Shojaie, Maryam Nemati, Sara Jafarzadeh, Hossein Bannazadeh Baghi, Michael R. Hamblin, Seyed Amirreza Akhlagh, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

The microRNA, miR-155 regulates both adaptive and innate immune responses. In viral infections, miR-155 can affect both innate immunity (interferon response, natural killer cell activity, and macrophage polarization) and adaptive immunity (including generation of anti-viral antibodies, CD8+ cytotoxic T lymphocytes, Th17, Th2, Th1, Tfh and Treg cells). In many viral infections, the proper and timely regulation of miR-155 expression is critical for the induction of an effective anti-virus immune response and viral clearance without any harmful immunopathologic consequences. MiR-155 may also exert pro-viral effects, mainly through the inhibition of the anti-viral interferon response. Thus, dysregulated expression of miR-155 can result in virus persistence and disruption of the normal response to viral infections. This review provides a thorough discussion of the role of miR-155 in immune responses and immunopathologic reactions during viral infections, and highlights its potential as a therapeutic target.

Original languageEnglish
Article number108188
JournalInternational Immunopharmacology
Volume101
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Antiviral immunity
  • MicroRNA-155
  • Pathogenesis
  • T cells
  • Viral infections

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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