Metal-based nanoparticles for bone tissue engineering

Reza Eivazzadeh-Keihan, Ehsan Bahojb Noruzi, Karim Khanmohammadi Chenab, Amir Jafari, Fateme Radinekiyan, Seyed Masoud Hashemi, Farnoush Ahmadpour, Ali Behboudi, Jafar Mosafer, Ahad Mokhtarzadeh, Ali Maleki, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

117 Citations (Scopus)


Tissue is vital to the organization of multicellular organisms, because it creates the different organs and provides the main scaffold for body shape. The quest for effective methods to allow tissue regeneration and create scaffolds for new tissue growth has intensified in recent years. Tissue engineering has recently used some promising alternatives to existing conventional scaffold materials, many of which have been derived from nanotechnology. One important example of these is metal nanoparticles. The purpose of this review is to cover novel tissue engineering methods, paying special attention to those based on the use of metal-based nanoparticles. The unique physiochemical properties of metal nanoparticles, such as antibacterial effects, shape memory phenomenon, low cytotoxicity, stimulation of the proliferation process, good mechanical and tensile strength, acceptable biocompatibility, significant osteogenic potential, and ability to regulate cell growth pathways, suggest that they can perform as novel types of scaffolds for bone tissue engineering. The basic principles of various nanoparticle-based composites and scaffolds are discussed in this review. The merits and demerits of these particles are critically discussed, and their importance in bone tissue engineering is highlighted.

Original languageEnglish
Pages (from-to)1687-1714
Number of pages28
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number12
Publication statusPublished - Dec 2020
Externally publishedYes


  • bone growth
  • magnetic nanoparticles
  • metal nanoparticles
  • scaffold
  • tissue engineering

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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