Mechanistic aspects of photobiomodulation therapy in the nervous system

Fatemeh Ramezani; Ali Neshasteh-Riz; Alireza Ghadaksaz; Seyedalireza Moghadas Fazeli; Atousa Janzadeh; Michael R. Hamblin

doi:10.1007/s10103-021-03277-2

Mechanistic aspects of photobiomodulation therapy in the nervous system

Fatemeh Ramezani, Ali Neshasteh-Riz, Alireza Ghadaksaz, Seyedalireza Moghadas Fazeli, Atousa Janzadeh, Michael R. Hamblin

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

36 Citations (Scopus)

Abstract

Photobiomodulation therapy (PBMT) previously known as low-level laser therapy (LLLT) has been used for over 30 years, to treat neurological diseases. Low-powered lasers are commonly used for clinical applications, although recently LEDs have become popular. Due to the growing application of this type of laser in brain and neural-related diseases, this review focuses on the mechanisms of laser action. The most important points to consider include the photon absorption by intracellular structures; the effect on the oxidative state of cells; and the effect on the expression of proteins involved in oxidative stress, inflammation, pain, and neuronal growth.

Original language	English
Pages (from-to)	11-18
Number of pages	8
Journal	Lasers in Medical Science
Volume	37
Issue number	1
DOIs	https://doi.org/10.1007/s10103-021-03277-2
Publication status	Published - Feb 2022

Keywords

Low-level laser therapy
Mechanisms
Neuronal cells
Oxidative stress
Photobiomodulation therapy

ASJC Scopus subject areas

Surgery
Dermatology

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10.1007/s10103-021-03277-2

Cite this

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abstract = "Photobiomodulation therapy (PBMT) previously known as low-level laser therapy (LLLT) has been used for over 30 years, to treat neurological diseases. Low-powered lasers are commonly used for clinical applications, although recently LEDs have become popular. Due to the growing application of this type of laser in brain and neural-related diseases, this review focuses on the mechanisms of laser action. The most important points to consider include the photon absorption by intracellular structures; the effect on the oxidative state of cells; and the effect on the expression of proteins involved in oxidative stress, inflammation, pain, and neuronal growth.",

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AU - Ramezani, Fatemeh

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AU - Janzadeh, Atousa

AU - Hamblin, Michael R.

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Mechanistic aspects of photobiomodulation therapy in the nervous system

Abstract

Keywords

ASJC Scopus subject areas

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