TY - GEN
T1 - Laser irradiation in the visible wavelength stimulates wound healing in vitro
AU - Houreld, N. N.
PY - 2012
Y1 - 2012
N2 - Low intensity laser irradiation (LILI) has been applied to stimulate healing in a variety of conditions, such as diabetes. This study aimed to determine the biochemical and molecular responses to LILI in the visible red spectrum. Various cell culture models, namely wounded, diabetic wounded and hypoxic/ischemic were used. Models were exposed to visible red laser light (632.8, 636 or 660 nm) at a fluence of 5 J/cm2. Post-irradiation, the effect on cells was studied. Laser irradiation was shown to have a positive effect on stressed cells in vitro. There was an increase in migration, cell survival and proliferation, mitochondrial activity, secondary messengers and collagen. A decrease in cytotoxicity, DNA damage and pro-inflammatory cytokines were also seen. LLLT offers an alternative wound healing therapy. At a biochemical level there was a positive effect on cells, with stressed cells being pushed into cell survival pathways.
AB - Low intensity laser irradiation (LILI) has been applied to stimulate healing in a variety of conditions, such as diabetes. This study aimed to determine the biochemical and molecular responses to LILI in the visible red spectrum. Various cell culture models, namely wounded, diabetic wounded and hypoxic/ischemic were used. Models were exposed to visible red laser light (632.8, 636 or 660 nm) at a fluence of 5 J/cm2. Post-irradiation, the effect on cells was studied. Laser irradiation was shown to have a positive effect on stressed cells in vitro. There was an increase in migration, cell survival and proliferation, mitochondrial activity, secondary messengers and collagen. A decrease in cytotoxicity, DNA damage and pro-inflammatory cytokines were also seen. LLLT offers an alternative wound healing therapy. At a biochemical level there was a positive effect on cells, with stressed cells being pushed into cell survival pathways.
UR - http://www.scopus.com/inward/record.url?scp=84902449048&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84902449048
SN - 9788875876777
T3 - Proceedings of the 9th World Association for Laser Therapy Congress, WALT 2012
SP - 41
EP - 44
BT - Proceedings of the 9th World Association for Laser Therapy Congress, WALT 2012
PB - MEDIMOND s.r.l.
T2 - 9th World Association for Laser Therapy Congress, WALT 2012
Y2 - 28 September 2012 through 30 September 2012
ER -
