TY - JOUR
T1 - Ki-67 expression as a diagnostic biomarker in odontogenic cysts and tumors
T2 - A systematic review and meta-analysis
AU - Jabbarzadeh, Mahnaz
AU - Hamblin, Michael R.
AU - Pournaghi-Azar, Fatemeh
AU - Saatloo, Maedeh Vakili
AU - Kouhsoltani, Maryam
AU - Vahed, Nafiseh
N1 - Publisher Copyright:
© 2021 The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Ki-67 is a marker of cell proliferation, used as an important diagnostic marker in the pathologic differentiation of various lesions. It is also relevant for developing targeted molecular therapies. We carried out a systematic review to assess the Ki-67 labeling index (LI) in odontogenic cysts and tumors. Databases were searched, including PubMed (MEDLINE), Scopus, CINHAL, PsycoInfo, the Cochrane Library, and Proquest. The meta-analysis was carried out based on the data of 608 lesions. When a 5% cut-off point was set, ki-67 LI of all benign odontogenic tumors dropped below this point. All the malignant tumors demonstrated an LI of over 15.3%; a significantly higher Ki-67 LI in malignant odontogenic lesions (17.59 ± 2.80) was observed. Among benign tumors, the largest and the smallest Ki-67 LIs were seen in ameloblastoma (4.39 ± 0.47) and adenomatoid odontogenic tumor (0.91 ± 1.71). The mean values of Ki-67 LI in tumors and cysts were 4.23 (0.38) and 1.04 (0.07), respectively. Among odontogenic cysts, the highest Ki-67 LI was found in odontogenic keratocyst (OKC) (3.58 ± 0.51), and the lowest in the radicular cyst (1.29 ± 0.62%). Ki-67 LIs in all odontogenic cysts were <3%, except for OKC. This controversial lesion seems to have a profile more similar to a tumor, and a treatment plan similar to tumors might be suggested. We found that odontogenic lesions have diverse proliferative activities that help differentiate between various lesions and suggest therapeutic plans.
AB - Ki-67 is a marker of cell proliferation, used as an important diagnostic marker in the pathologic differentiation of various lesions. It is also relevant for developing targeted molecular therapies. We carried out a systematic review to assess the Ki-67 labeling index (LI) in odontogenic cysts and tumors. Databases were searched, including PubMed (MEDLINE), Scopus, CINHAL, PsycoInfo, the Cochrane Library, and Proquest. The meta-analysis was carried out based on the data of 608 lesions. When a 5% cut-off point was set, ki-67 LI of all benign odontogenic tumors dropped below this point. All the malignant tumors demonstrated an LI of over 15.3%; a significantly higher Ki-67 LI in malignant odontogenic lesions (17.59 ± 2.80) was observed. Among benign tumors, the largest and the smallest Ki-67 LIs were seen in ameloblastoma (4.39 ± 0.47) and adenomatoid odontogenic tumor (0.91 ± 1.71). The mean values of Ki-67 LI in tumors and cysts were 4.23 (0.38) and 1.04 (0.07), respectively. Among odontogenic cysts, the highest Ki-67 LI was found in odontogenic keratocyst (OKC) (3.58 ± 0.51), and the lowest in the radicular cyst (1.29 ± 0.62%). Ki-67 LIs in all odontogenic cysts were <3%, except for OKC. This controversial lesion seems to have a profile more similar to a tumor, and a treatment plan similar to tumors might be suggested. We found that odontogenic lesions have diverse proliferative activities that help differentiate between various lesions and suggest therapeutic plans.
KW - Biomarker
KW - Ki-67 labeling index
KW - Odontogenic cysts
KW - Odontogenic tumor
UR - http://www.scopus.com/inward/record.url?scp=85118420956&partnerID=8YFLogxK
U2 - 10.34172/joddd.2021.012
DO - 10.34172/joddd.2021.012
M3 - Review article
AN - SCOPUS:85118420956
SN - 2008-210X
VL - 15
SP - 66
EP - 75
JO - Journal of Dental Research, Dental Clinics, Dental Prospects
JF - Journal of Dental Research, Dental Clinics, Dental Prospects
IS - 1
ER -