Ki-67 expression as a diagnostic biomarker in odontogenic cysts and tumors: A systematic review and meta-analysis

Mahnaz Jabbarzadeh, Michael R. Hamblin, Fatemeh Pournaghi-Azar, Maedeh Vakili Saatloo, Maryam Kouhsoltani, Nafiseh Vahed

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Ki-67 is a marker of cell proliferation, used as an important diagnostic marker in the pathologic differentiation of various lesions. It is also relevant for developing targeted molecular therapies. We carried out a systematic review to assess the Ki-67 labeling index (LI) in odontogenic cysts and tumors. Databases were searched, including PubMed (MEDLINE), Scopus, CINHAL, PsycoInfo, the Cochrane Library, and Proquest. The meta-analysis was carried out based on the data of 608 lesions. When a 5% cut-off point was set, ki-67 LI of all benign odontogenic tumors dropped below this point. All the malignant tumors demonstrated an LI of over 15.3%; a significantly higher Ki-67 LI in malignant odontogenic lesions (17.59 ± 2.80) was observed. Among benign tumors, the largest and the smallest Ki-67 LIs were seen in ameloblastoma (4.39 ± 0.47) and adenomatoid odontogenic tumor (0.91 ± 1.71). The mean values of Ki-67 LI in tumors and cysts were 4.23 (0.38) and 1.04 (0.07), respectively. Among odontogenic cysts, the highest Ki-67 LI was found in odontogenic keratocyst (OKC) (3.58 ± 0.51), and the lowest in the radicular cyst (1.29 ± 0.62%). Ki-67 LIs in all odontogenic cysts were <3%, except for OKC. This controversial lesion seems to have a profile more similar to a tumor, and a treatment plan similar to tumors might be suggested. We found that odontogenic lesions have diverse proliferative activities that help differentiate between various lesions and suggest therapeutic plans.

Original languageEnglish
Pages (from-to)66-75
Number of pages10
JournalJournal of Dental Research, Dental Clinics, Dental Prospects
Issue number1
Publication statusPublished - 1 Dec 2021


  • Biomarker
  • Ki-67 labeling index
  • Odontogenic cysts
  • Odontogenic tumor

ASJC Scopus subject areas

  • General Dentistry


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