Isoprenylated flavonoids from the stem bark of Erythrina abyssinica

Long Cui; Derek Tantoh Ndinteh; Min Kyun Na; Phuong Thien Thuong; John Silike-Muruumu; Dieudonné Njamen; Joseph Tanyi Mbafor; Zacharias Tanee Fomum; Seog Ann Jong; Keun Oh Won

doi:10.1021/np060477+

Isoprenylated flavonoids from the stem bark of Erythrina abyssinica

Long Cui, Derek Tantoh Ndinteh, Min Kyun Na, Phuong Thien Thuong, John Silike-Muruumu, Dieudonné Njamen, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Seog Ann Jong, Keun Oh Won

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC₅₀ values ranging from 14.2 ± 1.7 to 26.7 ± 1.2 μM.

Original language	English
Pages (from-to)	1039-1042
Number of pages	4
Journal	Journal of Natural Products
Volume	70
Issue number	6
DOIs	https://doi.org/10.1021/np060477+
Publication status	Published - Jun 2007
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and Alternative Medicine
Organic Chemistry

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title = "Isoprenylated flavonoids from the stem bark of Erythrina abyssinica",

abstract = "Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 ± 1.7 to 26.7 ± 1.2 μM.",

author = "Long Cui and Ndinteh, {Derek Tantoh} and Na, {Min Kyun} and Thuong, {Phuong Thien} and John Silike-Muruumu and Dieudonn{\'e} Njamen and Mbafor, {Joseph Tanyi} and Fomum, {Zacharias Tanee} and Jong, {Seog Ann} and Won, {Keun Oh}",

year = "2007",

month = jun,

doi = "10.1021/np060477+",

language = "English",

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T1 - Isoprenylated flavonoids from the stem bark of Erythrina abyssinica

AU - Cui, Long

AU - Ndinteh, Derek Tantoh

AU - Na, Min Kyun

AU - Thuong, Phuong Thien

AU - Silike-Muruumu, John

AU - Njamen, Dieudonné

AU - Mbafor, Joseph Tanyi

AU - Fomum, Zacharias Tanee

AU - Jong, Seog Ann

AU - Won, Keun Oh

PY - 2007/6

Y1 - 2007/6

N2 - Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 ± 1.7 to 26.7 ± 1.2 μM.

AB - Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 ± 1.7 to 26.7 ± 1.2 μM.

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JO - Journal of Natural Products

JF - Journal of Natural Products

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ER -

Isoprenylated flavonoids from the stem bark of Erythrina abyssinica

Abstract

ASJC Scopus subject areas

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