Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma

Pawel Mroz, Yumin Xia, Daisuke Asanuma, Aaron Konopko, Timur Zhiyentayev, Ying Ying Huang, Sulbha K. Sharma, Tianhong Dai, Usman J. Khan, Tim Wharton, Michael R. Hamblin

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Functionalized fullerenes represent a new class of photosensitizer (PS) that is being investigated for photodynamic therapy (PDT) of various diseases, including cancer. We tested the hypothesis that fullerenes could be used to mediate PDT of intraperitoneal (IP) carcinomatosis in a mouse model. In humans this form of cancer responds poorly to standard treatment and manifests as a thin covering of tumor nodules on intestines and on other abdominal organs. We used a colon adenocarcinoma cell line (CT26) stably expressing luciferase to allow monitoring of IP tumor burden in BALB/c mice by noninvasive real-time optical imaging using a sensitive low-light camera. IP injection of a preparation of N-methylpyrrolidinium-fullerene formulated in Cremophor-EL micelles, followed by white-light illumination delivered through the peritoneal wall (after creation of a skin flap), produced a statistically significant reduction in bioluminescence and a survival advantage in mice. From the Clinical Editor: This team of investigators report on functionalized fullerenes, to be used as photosensitizer for photodynamic therapy and demonstrate the efficacy of this method in an intraperitoneal carcinomatosis mouse model.

Original languageEnglish
Pages (from-to)965-974
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number6
Publication statusPublished - Dec 2011
Externally publishedYes


  • Disseminated abdominal cancer
  • Functionalized fullerene
  • Hydroxyl radicals
  • Micellar formulation
  • Photodynamic therapy

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • General Materials Science
  • Pharmaceutical Science


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