TY - JOUR
T1 - Interplay between SOX9 transcription factor and microRNAs in cancer
AU - Ashrafizadeh, Milad
AU - Zarrabi, Ali
AU - Orouei, Sima
AU - Zabolian, Amirhossein
AU - Saleki, Hossein
AU - Azami, Negar
AU - Bejandi, Atefe Kazemzade
AU - Mirzaei, Sepideh
AU - Janaghard, Milad Nemati
AU - Hushmandi, Kiavash
AU - Nabavi, Noushin
AU - Baradaran, Behzad
AU - Kumar, Alan Prem
AU - Makvandi, Pooyan
AU - Samarghandian, Saeed
AU - Khan, Haroon
AU - Hamblin, Michael R.
N1 - Publisher Copyright:
© 2021
PY - 2021/7/31
Y1 - 2021/7/31
N2 - SOX transcription factors are critical regulators of development, homeostasis and disease progression and their dysregulation is a common finding in various cancers. SOX9 belongs to SOXE family located on chromosome 17. MicroRNAs (miRNAs) possess the capacity of regulating different transcription factors in cancer cells by binding to 3′-UTR. Since miRNAs can affect differentiation, migration, proliferation and other physiological mechanisms, disturbances in their expression have been associated with cancer development. In this review, we evaluate the relationship between miRNAs and SOX9 in different cancers to reveal how this interaction can affect proliferation, metastasis and therapy response of cancer cells. The tumor-suppressor miRNAs can decrease the expression of SOX9 by binding to the 3′-UTR of mRNAs. Furthermore, the expression of downstream targets of SOX9, such as c-Myc, Wnt, PI3K/Akt can be affected by miRNAs. It is noteworthy that other non-coding RNAs including lncRNAs and circRNAs regulate miRNA/SOX9 expression to promote/inhibit cancer progression and malignancy. The pre-clinical findings can be applied as biomarkers for diagnosis and prognosis of cancer patients.
AB - SOX transcription factors are critical regulators of development, homeostasis and disease progression and their dysregulation is a common finding in various cancers. SOX9 belongs to SOXE family located on chromosome 17. MicroRNAs (miRNAs) possess the capacity of regulating different transcription factors in cancer cells by binding to 3′-UTR. Since miRNAs can affect differentiation, migration, proliferation and other physiological mechanisms, disturbances in their expression have been associated with cancer development. In this review, we evaluate the relationship between miRNAs and SOX9 in different cancers to reveal how this interaction can affect proliferation, metastasis and therapy response of cancer cells. The tumor-suppressor miRNAs can decrease the expression of SOX9 by binding to the 3′-UTR of mRNAs. Furthermore, the expression of downstream targets of SOX9, such as c-Myc, Wnt, PI3K/Akt can be affected by miRNAs. It is noteworthy that other non-coding RNAs including lncRNAs and circRNAs regulate miRNA/SOX9 expression to promote/inhibit cancer progression and malignancy. The pre-clinical findings can be applied as biomarkers for diagnosis and prognosis of cancer patients.
KW - Cancer
KW - Circular RNA
KW - Long non-coding RNA
KW - MicroRNA
KW - SOX9
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=85105272740&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2021.04.185
DO - 10.1016/j.ijbiomac.2021.04.185
M3 - Review article
C2 - 33957202
AN - SCOPUS:85105272740
SN - 0141-8130
VL - 183
SP - 681
EP - 694
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -
