Abstract
Covalently grafted KolliphorEL (a poly(ethylene glycol)-based transporter molecule for hydrophobic water-insoluble drugs; MW, ca. 2486; diameter, ca. 3 nm) at the surface of a glassy-carbon electrode strongly affects the rate of electron transfer for aqueous redox systems such as Fe(CN)63-/4-. XPS data confirm monolayer grafting after electrochemical anodization in pure KolliphorEL. On the basis of voltammetry and impedance measurements, the charge transfer process for the Fe(CN)63-/4- probe molecule is completely blocked after KolliphorEL grafting and in the absence of a "guest". However, in the presence of low concentrations of suitable ferrocene derivatives as guests, mediated electron transfer across the monolayer via a shuttle mechanism is observed. The resulting amplification of the ferrocene electroanalytical signal is investigated systematically and compared for five ferrocene derivatives. The low-concentration electron shuttle efficiency decreases in the following sequence: (dimethylaminomethyl)ferrocene > n-butyl ferrocene > ferrocene dimethanol > ferroceneacetonitrile > ferroceneacetic acid.
Original language | English |
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Pages (from-to) | 15464-15465 |
Number of pages | 2 |
Journal | ACS applied materials & interfaces |
Volume | 7 |
Issue number | 28 |
DOIs | |
Publication status | Published - 22 Jul 2015 |
Externally published | Yes |
Keywords
- Cremophor
- PEGylation
- amplification
- sensor
- tunneling
- voltammetry
ASJC Scopus subject areas
- General Materials Science