Inorganic layered double hydroxides as a 4-hexyl resorcinol delivery system for topical applications

Damodar Mosangi, Sreejarani Kesavan Pillai, Lumbidzani Moyo, Suprakas Sinha Ray

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

In this study, the hydrophobic even skin tone active, 4-hexylresorcinol (HR), was intercalated into a zinc aluminium layered double hydroxide (ZnAl-LDH) by a co-precipitation method and used as a controlled release ingredient in skin care formulation. The resulting nanohybrid (LDH-HR) was characterized using different techniques: XRD, FTIR, TEM, SEM, and TGA. The intercalation reaction between HR and LDH was confirmed using XRD, and FTIR. Some extent of aggregation was observed for the LDH-HR nanoparticles from TEM and SEM results. The thermal behaviour of HR drastically improved after intercalation into the LDH host. Strong electrostatic interactions between the HR and ZnAl-LDH galleries in the nanohybrid and the sustained release of HR from the LDH-HR in phosphate buffered saline (PBS) were observed. We also investigated the de-pigmenting efficiency of the LDH-HR nanohybrid containing formulations in randomized controlled experiments, which showed impressive results after 14 days of topical applications. The LDH-HR nanohybrid significantly minimized the melanogenesis in primary human melanocytes, resulting in overall improvements in even skin tone. Based on the above results, we believe that the LDH-HR nanohybrid has high potential for use as an alternative active ingredient in topical applications for uneven skin tone.

Original languageEnglish
Pages (from-to)77709-77716
Number of pages8
JournalRSC Advances
Volume6
Issue number81
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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