Inhibition of Lung Cancer Stem Cell Migration and Growth Through Nano-Photodynamic Therapy

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Abstract

Recurrence and post-treatment spreading of lung cancer signify the existence of drug-resistant cancer stem cells (CSCs) that withstand current therapies. The development of metastases and secondary tumors is a primary contributor to mortality. CSCs play a pivotal role in driving cellular invasion and have a critical impact on prognosis. Enhancing treatment outcomes involves the targeted elimination of CSCs while preserving healthy tissue. In this laboratory-based investigation, Photodynamic Therapy (PDT), a minimally invasive treatment, was employed alongside a nano drug carrier for lung cancer. PDT operates by inducing light-triggered cell death using a photosensitizing drug. When coupled with gold nanoparticles, this nano-mediated PDT facilitated cell death specifically in lung CSCs. The study’s objective was to assess the impact on normal lung cells and isolated CSCs, considering aspects such as cellular structure, migratory ability, proliferation, toxicity, doubling time, and the cell cycle. The results revealed minimal effects on normal lung cells, a reduction in CSC migration and invasion, the initiation of cell cycle arrest, and a decrease in CSC proliferation. Utilizing a drug nano carrier like AuNPs significantly enhanced the efficacy of PDT, with a specific focus on curtailing CSC-mediated dissemination in lung cancer, ultimately leading to an improved prognosis.

Original languageEnglish
Article number040301
JournalJournal of Biomedical Photonics and Engineering
Volume10
Issue number4
DOIs
Publication statusPublished - 2024

Keywords

  • dissemination
  • gold nano sensitizer
  • lung cancer stem cells
  • photodynamic therapy

ASJC Scopus subject areas

  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Acoustics and Ultrasonics

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