Influence of metal complex formation on heavy metal and free EDTA and DTPA acute toxicity determined by Daphnia magna

Jaana Sorvari; Mika Sillanpää

doi:10.1016/0045-6535(96)00251-2

Influence of metal complex formation on heavy metal and free EDTA and DTPA acute toxicity determined by Daphnia magna

Jaana Sorvari
, Mika Sillanpää

Aalto University

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

The EC₅₀ values (24h, Daphnia magna) of Fe³⁺, Cu²⁺, Mn²⁺, Zn²⁺, Cd²⁺ and Hg²⁺ complexed by EDTA or DTPA were compared with those of the respective uncomplexed metals and free EDTA and DTPA. The experiments gave the following toxicity order: Hg²⁺ > Cu²⁺ > Cd²⁺ > Zn²⁺ > Fe³⁺ > Mn²⁺. After complexation, the toxicities were 1.1 - 1700 (EDTA) and 7.0 - 3400 (DTPA) times lower. With Hg²⁺ however, complexation did not decrease the toxicity. Excluding Cd-DTPA, the toxicity reductions had a high correlation with the conditional stability constants of the respective metal chelates. Compared with the toxicity of free EDTA and DTPA; metal complexation increased the toxicity of EDTA and DTPA considerably. The results of the previous Microtox® study were well in accordance with this investigation.

Original language	English
Pages (from-to)	1119-1127
Number of pages	9
Journal	Chemosphere
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/0045-6535(96)00251-2
Publication status	Published - 1996
Externally published	Yes

Keywords

Acute toxicity
Complexation
DTPA
Daphnia magna
EDTA
Metal

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(96)00251-2

Cite this

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title = "Influence of metal complex formation on heavy metal and free EDTA and DTPA acute toxicity determined by Daphnia magna",

abstract = "The EC50 values (24h, Daphnia magna) of Fe3+, Cu2+, Mn2+, Zn2+, Cd2+ and Hg2+ complexed by EDTA or DTPA were compared with those of the respective uncomplexed metals and free EDTA and DTPA. The experiments gave the following toxicity order: Hg2+ > Cu2+ > Cd2+ > Zn2+ > Fe3+ > Mn2+. After complexation, the toxicities were 1.1 - 1700 (EDTA) and 7.0 - 3400 (DTPA) times lower. With Hg2+ however, complexation did not decrease the toxicity. Excluding Cd-DTPA, the toxicity reductions had a high correlation with the conditional stability constants of the respective metal chelates. Compared with the toxicity of free EDTA and DTPA; metal complexation increased the toxicity of EDTA and DTPA considerably. The results of the previous Microtox{\textregistered} study were well in accordance with this investigation.",

keywords = "Acute toxicity, Complexation, DTPA, Daphnia magna, EDTA, Metal",

author = "Jaana Sorvari and Mika Sillanp{\"a}{\"a}",

year = "1996",

doi = "10.1016/0045-6535(96)00251-2",

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pages = "1119--1127",

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TY - JOUR

T1 - Influence of metal complex formation on heavy metal and free EDTA and DTPA acute toxicity determined by Daphnia magna

AU - Sorvari, Jaana

AU - Sillanpää, Mika

PY - 1996

Y1 - 1996

N2 - The EC50 values (24h, Daphnia magna) of Fe3+, Cu2+, Mn2+, Zn2+, Cd2+ and Hg2+ complexed by EDTA or DTPA were compared with those of the respective uncomplexed metals and free EDTA and DTPA. The experiments gave the following toxicity order: Hg2+ > Cu2+ > Cd2+ > Zn2+ > Fe3+ > Mn2+. After complexation, the toxicities were 1.1 - 1700 (EDTA) and 7.0 - 3400 (DTPA) times lower. With Hg2+ however, complexation did not decrease the toxicity. Excluding Cd-DTPA, the toxicity reductions had a high correlation with the conditional stability constants of the respective metal chelates. Compared with the toxicity of free EDTA and DTPA; metal complexation increased the toxicity of EDTA and DTPA considerably. The results of the previous Microtox® study were well in accordance with this investigation.

AB - The EC50 values (24h, Daphnia magna) of Fe3+, Cu2+, Mn2+, Zn2+, Cd2+ and Hg2+ complexed by EDTA or DTPA were compared with those of the respective uncomplexed metals and free EDTA and DTPA. The experiments gave the following toxicity order: Hg2+ > Cu2+ > Cd2+ > Zn2+ > Fe3+ > Mn2+. After complexation, the toxicities were 1.1 - 1700 (EDTA) and 7.0 - 3400 (DTPA) times lower. With Hg2+ however, complexation did not decrease the toxicity. Excluding Cd-DTPA, the toxicity reductions had a high correlation with the conditional stability constants of the respective metal chelates. Compared with the toxicity of free EDTA and DTPA; metal complexation increased the toxicity of EDTA and DTPA considerably. The results of the previous Microtox® study were well in accordance with this investigation.

KW - Acute toxicity

KW - Complexation

KW - DTPA

KW - Daphnia magna

KW - EDTA

KW - Metal

UR - https://www.scopus.com/pages/publications/0029764612

U2 - 10.1016/0045-6535(96)00251-2

DO - 10.1016/0045-6535(96)00251-2

M3 - Article

AN - SCOPUS:0029764612

SN - 0045-6535

VL - 33

SP - 1119

EP - 1127

JO - Chemosphere

JF - Chemosphere

IS - 6

ER -

Influence of metal complex formation on heavy metal and free EDTA and DTPA acute toxicity determined by Daphnia magna

Abstract

Keywords

ASJC Scopus subject areas

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