TY - JOUR
T1 - In vitro electron paramagnetic resonance (Epr) spectroscopy study on radical scavenging abilities of an extract isolated from stem bark of piptadeniastrum africanum tree
AU - Zheleva, Antoaneta M.
AU - Nikolova, Galina D.
AU - Karamalakova, Yanka D.
AU - Ndinteh, Derek T.
AU - Gadjeva, Veselina G.
N1 - Publisher Copyright:
© 2019, Academic Publishing House. All rights reserved.
PY - 2019
Y1 - 2019
N2 - The purpose of this study was to evaluate free radical scavenging abilities of an extract isolated from stem bark of Piptadeniastrum africanum (P. africa-num) tree by high sensitive Electron Paramagnetic Resonance (EPR) spectroscopy. The extract depending on concentrations exhibited in vitro high scavenging ability against the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Moreover, in vitro high scavenging activity towards superoxide ( • O − 2 ) and alkyl radicals was also found. Only in the Fenton system generating hydroxyl radicals studied extract showed pro-oxidant activity. Since in the studied in vitro systems P. africanum extract showed antioxidant and pro-oxidant properties as well, we believe that thorough and detailed studies should be carried out to clarify which components are involved in its pro-oxidant activity demonstrated in this study.
AB - The purpose of this study was to evaluate free radical scavenging abilities of an extract isolated from stem bark of Piptadeniastrum africanum (P. africa-num) tree by high sensitive Electron Paramagnetic Resonance (EPR) spectroscopy. The extract depending on concentrations exhibited in vitro high scavenging ability against the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Moreover, in vitro high scavenging activity towards superoxide ( • O − 2 ) and alkyl radicals was also found. Only in the Fenton system generating hydroxyl radicals studied extract showed pro-oxidant activity. Since in the studied in vitro systems P. africanum extract showed antioxidant and pro-oxidant properties as well, we believe that thorough and detailed studies should be carried out to clarify which components are involved in its pro-oxidant activity demonstrated in this study.
KW - Antioxidant activity
KW - Electron paramagnetic resonance
KW - Piptadeniastrum africanum
KW - Radical scavenging abilities
UR - http://www.scopus.com/inward/record.url?scp=85063350572&partnerID=8YFLogxK
U2 - 10.7546/CRABS.2019.02.07
DO - 10.7546/CRABS.2019.02.07
M3 - Article
AN - SCOPUS:85063350572
SN - 1310-1331
VL - 72
SP - 191
EP - 197
JO - Comptes Rendus de L'Academie Bulgare des Sciences
JF - Comptes Rendus de L'Academie Bulgare des Sciences
IS - 2
ER -
