Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Milad Ashrafizadeh; Sepideh Mirzaei; Mohammad Hossein Gholami; Farid Hashemi; Amirhossein Zabolian; Mehdi Raei; Kiavash Hushmandi; Ali Zarrabi; Nicolas H. Voelcker; Amir Reza Aref; Michael R. Hamblin; Rajender S. Varma; Saeed Samarghandian; I. J. Arostegi; M. Alzola; Alan Prem Kumar; Vijay Kumar Thakur; Noushin Nabavi; Pooyan Makvandi; Franklin R. Tay; Gorka Orive

doi:10.1016/j.carbpol.2021.118491

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Milad Ashrafizadeh
, Sepideh Mirzaei
, Mohammad Hossein Gholami
, Farid Hashemi
, Amirhossein Zabolian
, Mehdi Raei
, Kiavash Hushmandi
, Ali Zarrabi
, Nicolas H. Voelcker
, Amir Reza Aref
, Michael R. Hamblin
, Rajender S. Varma
, Saeed Samarghandian
, I. J. Arostegi
, M. Alzola
, Alan Prem Kumar
, Vijay Kumar Thakur
, Noushin Nabavi
, Pooyan Makvandi
, Franklin R. Tay

Gorka Orive

Laser Research Centre

Sabanci University
Islamic Azad University
University of Tehran
Baqiyatallah Medical Sciences University
Monash University
CSIRO
Victorian Node of the Australian National Fabrication Facility
Harvard University
Xsphera Biosciences Inc.
Iran University of Medical Sciences
Palacký University Olomouc
Neyshabur University of Medical Sciences
University of the Basque Country
National University of Singapore
Scotland's Rural College
Shiv Nadar University
University of British Columbia
Italian Institute of Technology
Augusta University
Biomaterials and Nanomedicine (CIBER-BBN)
University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua)
NanoBioCel Research Group
Singapore National Eye Center

Research output: Contribution to journal › Review article › peer-review

161 Citations (Scopus)

Abstract

An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

Original language	English
Article number	118491
Journal	Carbohydrate Polymers
Volume	272
DOIs	https://doi.org/10.1016/j.carbpol.2021.118491
Publication status	Published - 15 Nov 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CD44
Doxorubicin
Drug resistance
Endocytosis
Hyaluronic acid
Nanodelivery system
Theranostic

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

Access to Document

10.1016/j.carbpol.2021.118491

Cite this

Ashrafizadeh, M., Mirzaei, S., Gholami, M. H., Hashemi, F., Zabolian, A., Raei, M., Hushmandi, K., Zarrabi, A., Voelcker, N. H., Aref, A. R., Hamblin, M. R., Varma, R. S., Samarghandian, S., Arostegi, I. J., Alzola, M., Kumar, A. P., Thakur, V. K., Nabavi, N., Makvandi, P., ... Orive, G. (2021). Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression. Carbohydrate Polymers, 272, Article 118491. https://doi.org/10.1016/j.carbpol.2021.118491

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title = "Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression",

abstract = "An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.",

keywords = "CD44, Doxorubicin, Drug resistance, Endocytosis, Hyaluronic acid, Nanodelivery system, Theranostic",

author = "Milad Ashrafizadeh and Sepideh Mirzaei and Gholami, \{Mohammad Hossein\} and Farid Hashemi and Amirhossein Zabolian and Mehdi Raei and Kiavash Hushmandi and Ali Zarrabi and Voelcker, \{Nicolas H.\} and Aref, \{Amir Reza\} and Hamblin, \{Michael R.\} and Varma, \{Rajender S.\} and Saeed Samarghandian and Arostegi, \{I. J.\} and M. Alzola and Kumar, \{Alan Prem\} and Thakur, \{Vijay Kumar\} and Noushin Nabavi and Pooyan Makvandi and Tay, \{Franklin R.\} and Gorka Orive",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = nov,

day = "15",

doi = "10.1016/j.carbpol.2021.118491",

language = "English",

volume = "272",

journal = "Carbohydrate Polymers",

issn = "0144-8617",

publisher = "Elsevier Ltd.",

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Ashrafizadeh, M, Mirzaei, S, Gholami, MH, Hashemi, F, Zabolian, A, Raei, M, Hushmandi, K, Zarrabi, A, Voelcker, NH, Aref, AR, Hamblin, MR, Varma, RS, Samarghandian, S, Arostegi, IJ, Alzola, M, Kumar, AP, Thakur, VK, Nabavi, N, Makvandi, P, Tay, FR & Orive, G 2021, 'Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression', Carbohydrate Polymers, vol. 272, 118491. https://doi.org/10.1016/j.carbpol.2021.118491

TY - JOUR

T1 - Hyaluronic acid-based nanoplatforms for Doxorubicin

T2 - A review of stimuli-responsive carriers, co-delivery and resistance suppression

AU - Ashrafizadeh, Milad

AU - Mirzaei, Sepideh

AU - Gholami, Mohammad Hossein

AU - Hashemi, Farid

AU - Zabolian, Amirhossein

AU - Raei, Mehdi

AU - Hushmandi, Kiavash

AU - Zarrabi, Ali

AU - Voelcker, Nicolas H.

AU - Aref, Amir Reza

AU - Hamblin, Michael R.

AU - Varma, Rajender S.

AU - Samarghandian, Saeed

AU - Arostegi, I. J.

AU - Alzola, M.

AU - Kumar, Alan Prem

AU - Thakur, Vijay Kumar

AU - Nabavi, Noushin

AU - Makvandi, Pooyan

AU - Tay, Franklin R.

AU - Orive, Gorka

PY - 2021/11/15

Y1 - 2021/11/15

N2 - An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

AB - An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

KW - CD44

KW - Doxorubicin

KW - Drug resistance

KW - Endocytosis

KW - Hyaluronic acid

KW - Nanodelivery system

KW - Theranostic

UR - https://www.scopus.com/pages/publications/85111936989

U2 - 10.1016/j.carbpol.2021.118491

DO - 10.1016/j.carbpol.2021.118491

M3 - Review article

C2 - 34420747

AN - SCOPUS:85111936989

SN - 0144-8617

VL - 272

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

M1 - 118491

ER -

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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