Histological changes in the liver of Oreochromis mossambicus (Cichlidae) after exposure to cadmium and zinc

The toxic effects, of two heavy metals, cadmium (Cd) and zinc (Zn), on the histology of the liver of the southern African freshwater fish Oreochromis mossambicus, were investigated. The goal was to identify whether metal concentrations and exposure period influence the degree and nature of histological changes in the liver of exposed fish. Selected fish were exposed to a mixture of 5% concentrations of the LC₅₀ of cadmium and zinc and to a mixture of 10% concentrations of the LC₅₀ of cadmium and zinc, over both short- and long-term exposure periods. Similar histological changes occurred in the livers of specimens exposed to both 5% and 10% concentrations, indicating a definite toxic response to both the metal concentrations. These histological changes included hyalinization, hepatocyte vacuolation, cellular swelling, and congestion of blood vessels. The intensity of these histological changes was, however, influenced by the extent of the exposure period.