Hierarchically Assembled Two-dimensional Hybrid Nanointerfaces: A Platform for Bioelectronic Applications

Renu Kumari, Adeniyi Olugbenga Osikoya, William Wilson Anku, Sudheesh Kumar Shukla, Penny Poomani Govender

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS2) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS2/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS2/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS2/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H2O2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H2O2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm2.

Original languageEnglish
Pages (from-to)2339-2348
Number of pages10
Issue number10
Publication statusPublished - Oct 2018


  • MoS
  • Nanohybrid interface
  • bioelectronics
  • biosensors
  • two-dimensional (2D) nanointerfaces

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry


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