TY - JOUR
T1 - Hierarchically Assembled Two-dimensional Hybrid Nanointerfaces
T2 - A Platform for Bioelectronic Applications
AU - Kumari, Renu
AU - Osikoya, Adeniyi Olugbenga
AU - Anku, William Wilson
AU - Shukla, Sudheesh Kumar
AU - Govender, Penny Poomani
N1 - Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/10
Y1 - 2018/10
N2 - We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS2) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS2/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS2/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS2/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H2O2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H2O2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm2.
AB - We introduce a hybrid two-dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self-assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)-molybdenum disulfide (MoS2) layered nanohybrid, conjugated with poly (N-isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS2/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS2/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS2/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H2O2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H2O2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm2.
KW - MoS
KW - Nanohybrid interface
KW - bioelectronics
KW - biosensors
KW - two-dimensional (2D) nanointerfaces
UR - http://www.scopus.com/inward/record.url?scp=85050641887&partnerID=8YFLogxK
U2 - 10.1002/elan.201800338
DO - 10.1002/elan.201800338
M3 - Article
AN - SCOPUS:85050641887
SN - 1040-0397
VL - 30
SP - 2339
EP - 2348
JO - Electroanalysis
JF - Electroanalysis
IS - 10
ER -