Abstract
The anti-retroviral nevirapine has been detected in surface waters throughout South Africa and its effects on non-target aquatic animals are still unknown. The aim was to investigate the potential effects of nevirapine on the hatching success and survival of Oreochromis mossambicus early life stages through a chronic exposure. The exposer started with newly fertilized O. mossambicus eggs and concluded 30 days after hatching. Environmental relevant concentration of nevirapine (1.48 µg/l) was used in a static renewal system and a controlled environment (27 ± 1°C; 14:10 day/night cycle). The main endpoints assessed included hatching success and survival; a morphological assessment was also done on whole individual on day 1 and 30 post-hatching to identify any physical abnormality. Nevirapine had no noticeable effects on the hatching success and survival of O. mossambicus larvae; no statistically significant differences were observed between the control and the nevirapine exposed fish (p > 0.05).
| Original language | English |
|---|---|
| Pages (from-to) | 441-456 |
| Number of pages | 16 |
| Journal | International Journal of Environmental Health Research |
| Volume | 29 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 4 Jul 2019 |
Keywords
- HIV antiretrovirals
- O. mossambicus
- juveniles
- larvae
- surface waters
- survival
ASJC Scopus subject areas
- Pollution
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
