Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles

Zahra Sadat Razavi, Vida Tajiknia, Shahab Majidi, Maryam Ghandali, Hamid Reza Mirzaei, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

86 Citations (Scopus)

Abstract

Gynecologic cancers involve the female genital organs, such as the vulva, vagina, cervix, endometrium, ovaries, and fallopian tubes. The occurrence and frequency of gynecologic cancer depends on personal lifestyle, history of exposure to viruses or carcinogens, genetics, body shape, and geographical habitat. For a long time, research into the molecular biology of cancer was broadly restricted to protein-coding genes. Recently it has been realized that non-coding RNAs (ncRNA), including long noncoding RNAs (LncRNAs), microRNAs, circular RNAs and piRNAs (PIWI-interacting RNAs), can all play a role in the regulation of cellular function within gynecological cancer. It is now known that ncRNAs are able to play dual roles, i.e. can exert both oncogenic or tumor suppressive functions in gynecological cancer. Moreover, several clinical trials are underway looking at the biomarker and therapeutic roles of ncRNAs. These efforts may provide a new horizon for the diagnosis and treatment of gynecological cancer. Herein, we summarize some of the ncRNAs that have been shown to be important in gynecological cancers.

Original languageEnglish
Article number103192
JournalCritical Reviews in Oncology/Hematology
Volume157
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Cervical cancer
  • Circular RNAs
  • Endometrial cancer
  • Long noncoding RNAs
  • Micro-RNAs
  • Noncoding RNAs
  • Ovarian cancer
  • piRNAs

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology

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