Gum acacia polysaccharide-based pH sensitive gels for targeted delivery of neridronate

B. A. Aderibigbe, Suprakas Sinha Ray

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The preparation of polysaccharide-based gels from a combination of natural and synthetic polymers results in polymer networks with unique physicochemical properties. Polysaccharide-based gels were prepared from a combination of gum acacia, a polysaccharide, and synthetic polymers using the free radical polymerization technique. The gels were characterized by XRD, DSC, SEM, and FTIR. The swelling abilities of the gels were performed at pH 1.2 and 7.4. Release kinetic studies of neridronate from the prepared gels were performed and the release mechanism was found to be super case transport II at pH 1.2 and pH 7.4. The gels were pH sensitive and the release profile of neridronate from the gels network was influenced by the degree of cross-linking of their network and pH. The preliminary results suggest that these gels are promising devices for targeted delivery of neridronate to the gastrointestinal region.

Original languageEnglish
Pages (from-to)2641-2655
Number of pages15
JournalPolymer Bulletin
Volume74
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Gels
  • Gum acacia
  • Neridronate
  • Targeted drug delivery

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics
  • Polymers and Plastics
  • Materials Chemistry

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